Please use this identifier to cite or link to this item: https://doi.org/10.1021/bm050318p
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dc.titleFormation of collagen - Glycosaminoglycan blended nanofibrous scaffolds and their biological properties
dc.contributor.authorZhong, S.
dc.contributor.authorTeo, W.E.
dc.contributor.authorZhu, X.
dc.contributor.authorBeuerman, R.
dc.contributor.authorRamakrishna, S.
dc.contributor.authorYung, L.Y.L.
dc.date.accessioned2014-06-17T06:22:16Z
dc.date.available2014-06-17T06:22:16Z
dc.date.issued2005-11
dc.identifier.citationZhong, S., Teo, W.E., Zhu, X., Beuerman, R., Ramakrishna, S., Yung, L.Y.L. (2005-11). Formation of collagen - Glycosaminoglycan blended nanofibrous scaffolds and their biological properties. Biomacromolecules 6 (6) : 2998-3004. ScholarBank@NUS Repository. https://doi.org/10.1021/bm050318p
dc.identifier.issn15257797
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/60358
dc.description.abstractThe development of blended collagen and glycosaminoglycan (GAG) scaffolds can potentially be used in many soft tissue engineering applications since the scaffolds mimic the structure and biological function of native extracellular matrix (ECM). In this study, we were able to obtain novel nanofibrous collagen-GAG scaffolds by electrospinning collagen blended with chondroitin sulfate (CS), a widely used GAG, in a mixed solvent of trifluoroethanol and water. The electrospun collagen-GAG scaffold with 4% CS (COLL-CS-04) exhibited a uniform fiber structure with nanoscale diameters. A second collagen-GAG scaffold with 10% CS consisted of smaller diameter fibers but exhibited a broader diameter distribution due to the different solution properties in comparison with COLL-CS-04. After cross-linking with glutaraldehyde vapor, the collagen-GAG scaffolds became more biostable and were resistant to collagenase degradation. This is evidently a more favorable environment allowing increased proliferation of rabbit conjunctiva fibroblast on the scaffolds. Incorporation of CS into collagen nanofibers without cross-linking did not increase the biostability but still promoted cell growth. The potential of applying the nanoscale collagen-GAG scaffold in tissue engineering is significant since the nanodimension fibers made of natural ECM mimic closely the native ECM found in the human body. The high-surface area characteristic of this scaffold may maximize cell-ECM interaction and promote tissue regeneration faster than other conventional scaffolds. © 2005 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/bm050318p
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1021/bm050318p
dc.description.sourcetitleBiomacromolecules
dc.description.volume6
dc.description.issue6
dc.description.page2998-3004
dc.description.codenBOMAF
dc.identifier.isiut000233392100016
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