Please use this identifier to cite or link to this item:
Title: Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: Accelerated versus simulated physiological conditions
Authors: Lam, C.X.F. 
Savalani, M.M.
Teoh, S.-H. 
Hutmacher, D.W. 
Issue Date: 1-Sep-2008
Citation: Lam, C.X.F., Savalani, M.M., Teoh, S.-H., Hutmacher, D.W. (2008-09-01). Dynamics of in vitro polymer degradation of polycaprolactone-based scaffolds: Accelerated versus simulated physiological conditions. Biomedical Materials 3 (3) : -. ScholarBank@NUS Repository.
Abstract: The increasing use of biodegradable devices in tissue engineering and regenerative medicine means it is essential to study and understand their degradation behaviour. Accelerated degradation systems aim to achieve similar degradation profiles within a shorter period of time, compared with standard conditions. However, these conditions only partially mimic the actual situation, and subsequent analyses and derived mechanisms must be treated with caution and should always be supported by actual long-term degradation data obtained under physiological conditions. Our studies revealed that polycaprolactone (PCL) and PCL-composite scaffolds degrade very differently under these different degradation conditions, whilst still undergoing hydrolysis. Molecular weight and mass loss results differ due to the different degradation pathways followed (surface degradation pathway for accelerated conditions and bulk degradation pathway for simulated physiological conditions). Crystallinity studies revealed similar patterns of recrystallization dynamics, and mechanical data indicated that the scaffolds retained their functional stability, in both instances, over the course of degradation. Ultimately, polymer degradation was shown to be chiefly governed by molecular weight, crystallinity susceptibility to hydrolysis and device architecture considerations whilst maintaining its thermodynamic equilibrium. © 2008 IOP Publishing Ltd.
Source Title: Biomedical Materials
ISSN: 17486041
DOI: 10.1088/1748-6041/3/3/034108
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Apr 13, 2021


checked on Apr 13, 2021

Page view(s)

checked on Apr 13, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.