Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jbiomech.2005.11.005
DC FieldValue
dc.titleAn analytical study on the thermal effects of cryosurgery on selective cell destruction
dc.contributor.authorChua, K.J.
dc.contributor.authorChou, S.K.
dc.contributor.authorHo, J.C.
dc.date.accessioned2014-06-17T06:11:13Z
dc.date.available2014-06-17T06:11:13Z
dc.date.issued2007
dc.identifier.citationChua, K.J., Chou, S.K., Ho, J.C. (2007). An analytical study on the thermal effects of cryosurgery on selective cell destruction. Journal of Biomechanics 40 (1) : 100-116. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jbiomech.2005.11.005
dc.identifier.issn00219290
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/59417
dc.description.abstractThe aim of cryosurgery is to kill cells within a closely defined region maintained at a predetermined low temperature. To effectively kill cells, it is important to be able to predict and control the cooling rate over some critical range of temperatures and freezing states in order to regulate the spatial extent of injury during any freeze-thaw protocol. The objective of manipulating the freezing parameters is to maximize the destruction of cancer cells within a defined spatial domain while minimizing cryoinjury to the surrounding healthy tissue. An analytical model has been developed to study the rate of cell destruction within a liver tumor undergoing a freeze-thaw cryosurgical process. Temperature transients in the tumor undergoing cryosurgery have been quantitatively investigated. The simulation is based on solving the transient bioheat equation using the finite volume scheme for a single or multiple-probe geometry. Simulated results show good agreement with experimental data obtained from in vivo clinical study. The calibrated model has been employed to study the effects of different freezing rates, freeze-thaw cycle(s), and multi-probe freezing on cell damage in a liver tumor. The effectiveness of each treatment protocol is estimated by generating the cell survival-volume signature and comparing the percentage of cell damaged within the ice-ball. Results from the model show that employing freeze-thaw cycles has the potential to enhance cell destruction within the cancerous tissue. Results from this study provide the basis for designing an optimized cryosurgical protocol which incorporates thermal effects and the extent of cell destruction within tumors. © 2005 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jbiomech.2005.11.005
dc.sourceScopus
dc.subjectCooling rate
dc.subjectCryosurgery
dc.subjectFreeze-thaw
dc.subjectFreezing front
dc.typeArticle
dc.contributor.departmentMECHANICAL ENGINEERING
dc.description.doi10.1016/j.jbiomech.2005.11.005
dc.description.sourcetitleJournal of Biomechanics
dc.description.volume40
dc.description.issue1
dc.description.page100-116
dc.description.codenJBMCB
dc.identifier.isiut000243456700012
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

74
checked on Dec 2, 2020

WEB OF SCIENCETM
Citations

64
checked on Nov 24, 2020

Page view(s)

69
checked on Dec 1, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.