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|Title:||Robust computer-controlled system for intracytoplasmic sperm injection and subsequent cell electro-activation||Authors:||Tan, K.K.
|Keywords:||Intracytoplasmic sperm injection cell electro-activation computer-controlled system||Issue Date:||2009||Citation:||Tan, K.K., Huang, S., Tang, K.Z. (2009). Robust computer-controlled system for intracytoplasmic sperm injection and subsequent cell electro-activation. International Journal of Medical Robotics and Computer Assisted Surgery 5 (1) : 85-98. ScholarBank@NUS Repository. https://doi.org/10.1002/rcs.239||Abstract:||Introduction: Intracytoplasmic sperm injection (ICSI) and the subsequent cell electro-activation process is a relatively new enhanced procedure to address male factor infertility. The current method involves the engagement of experienced embryologists for such a purpose. More advanced methodologies, which use high precision instrumentation tools, will speed up the whole procedure. Methods: In this paper, the development of a computer-controlled system for ICSI and the subsequent cell electro-activation process is presented. The system is integrated to a microinjection workstation and piezo-actuator to perform the ICSI procedure, with vision capability to automatically position the components precisely. A micro-pump assembly is utilized for automatic medium refreshment and a heater plate assembly provides temperature control during the cell electro-activation process. The overall system is comprehensive, comprising modular functional components integrated within a hardware architecture. Results: Experimental results on mice oocytes verified the effectiveness of the developed system over the current method. Conclusions: Further improvements on the instrumentation tools will improve the robustness and overall performance of the developed system. Copyright © 2009 John Wiley & Sons, Ltd.||Source Title:||International Journal of Medical Robotics and Computer Assisted Surgery||URI:||http://scholarbank.nus.edu.sg/handle/10635/57295||ISSN:||14785951||DOI:||10.1002/rcs.239|
|Appears in Collections:||Staff Publications|
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