Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0042385
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dc.titleA quantitative model of human jejunal smooth muscle cell electrophysiology
dc.contributor.authorPoh, Y.C.
dc.contributor.authorCorrias, A.
dc.contributor.authorCheng, N.
dc.contributor.authorBuist, M.L.
dc.date.accessioned2014-06-16T09:34:26Z
dc.date.available2014-06-16T09:34:26Z
dc.date.issued2012-08-17
dc.identifier.citationPoh, Y.C., Corrias, A., Cheng, N., Buist, M.L. (2012-08-17). A quantitative model of human jejunal smooth muscle cell electrophysiology. PLoS ONE 7 (8) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0042385
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/54753
dc.description.abstractRecently, a number of ion channel mutations have been identified in the smooth muscle cells of the human jejunum. Although these are potentially significant in understanding diseases that are currently of unknown etiology, no suitable computational cell model exists to evaluate the effects of such mutations. Here, therefore, a biophysically based single cell model of human jejunal smooth muscle electrophysiology is presented. The resulting cellular description is able to reproduce experimentally recorded slow wave activity and produces realistic responses to a number of perturbations, providing a solid platform on which the causes of intestinal myopathies can be investigated. © 2012 Poh et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0042385
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1371/journal.pone.0042385
dc.description.sourcetitlePLoS ONE
dc.description.volume7
dc.description.issue8
dc.description.page-
dc.identifier.isiut000308063700014
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