Please use this identifier to cite or link to this item:
Title: A computational model of a class of gene networks with positive and negative controls
Authors: Chen, P.C.Y. 
Keywords: Automata
Formal languages
Gene networks
Positive and negative controls
Issue Date: Jan-2004
Citation: Chen, P.C.Y. (2004-01). A computational model of a class of gene networks with positive and negative controls. BioSystems 73 (1) : 13-24. ScholarBank@NUS Repository.
Abstract: This article proposes a computational framework for modelling the logical behavior of a class of gene networks. We characterize the basic behavior of genes in terms of a state-and-transition structure, and model the individual genes as language-generating automata. We consider positive and negative controls as the interaction mechanisms among the genes, and treat such controls as constraints (also expressed in automata) imposed on the behavior of the gene network. By computing the intersection of the languages generated by the gene models and the constraints, we obtain the complete set of pathways in a gene network. Implications and possible improvement of this work are discussed. © 2003 Elsevier Ireland Ltd. All rights reserved.
Source Title: BioSystems
ISSN: 03032647
DOI: 10.1016/j.biosystems.2003.07.002
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.