Please use this identifier to cite or link to this item:
https://scholarbank.nus.edu.sg/handle/10635/53804
DC Field | Value | |
---|---|---|
dc.title | STRUCTURE-FUNCTION RELATIONSHIPS AND ACTION MECHANISM OF KRAIT NATRIURETIC PEPTIDE | |
dc.contributor.author | SINDHUJA SRIDHARAN | |
dc.date.accessioned | 2014-06-11T18:00:28Z | |
dc.date.available | 2014-06-11T18:00:28Z | |
dc.date.issued | 2014-01-24 | |
dc.identifier.citation | SINDHUJA SRIDHARAN (2014-01-24). STRUCTURE-FUNCTION RELATIONSHIPS AND ACTION MECHANISM OF KRAIT NATRIURETIC PEPTIDE. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53804 | |
dc.description.abstract | Endogenous natriuretic peptides (NPs) are a class of potent vasoactive hormones, which maintain pressure-volume homeostasis. Snake venom NPs are structurally similar to endogenous NPs with a 17-residue ring but with variable C-terminal extension. In the present study, a unique NP from a krait , KNP, has been studied. Structurally, KNP has a 38-residue long C-terminal tail which has propensity to form a-helix. KNP induced vasorelaxation of aortic strip by a mechanism independent of NP receptors in contrast to canonical NPs. Deletion mutant study has revealed the presence of two functional pharmacophores; KNP ring and putative helix. Ring functions like a classical NP while Helix induces vasorelaxation in NP receptor independent manner like KNP. Thus, the helical segment in KNP?s C-tail seems to confer its bio-activity. KNP showed remarkable resistance (half-life >150 min) to degradation by neural endopeptidase. By specific substitutions, the key residues involved in conferring resistance have been identified. | |
dc.language.iso | en | |
dc.subject | Natriuretic peptide, blood pressure, cGMP, vasodilation, krait, venom | |
dc.type | Thesis | |
dc.contributor.department | BIOLOGICAL SCIENCES | |
dc.contributor.supervisor | KINI, R MANJUNATHA | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
Sindhuja Sridharan_ final thesis.pdf | 4.22 MB | Adobe PDF | OPEN | None | View/Download |
Google ScholarTM
Check
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.