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Title: Targeting Mitochondrial manganese superoxide dismutase to improve treatment of Breast carcinoma
Authors: LOO SER YUE
Keywords: breast cancer, chemotherapy, MnSOD, PPAR gamma
Issue Date: 16-Jan-2014
Citation: LOO SER YUE (2014-01-16). Targeting Mitochondrial manganese superoxide dismutase to improve treatment of Breast carcinoma. ScholarBank@NUS Repository.
Abstract: Breast carcinoma is one of the most common malignancies among women worldwide. Among the subtypes of breast cancer, the basal subtype is more invasive, metastatic and has a worst prognosis than the other subtypes. Finding a feasible strategy for the treatment of basal breast cancer is of utmost importance. Clinical screening of breast cancer patients revealed a high level of MnSOD in the basal subtype of breast cancer and we showed earlier that Peroxisome Proliferator-activated Receptor Gamma (PPAR?) is one possible approach for targeting of MnSOD. PPAR? activation downregulates MnSOD levels, which corresponds to an accumulation of mitochondria ROS and enhances chemo-sensitivity. Furthermore, we showed that PPAR? is under epigenetic regulation and that treatment with histone deacetyase inhibitors (HDACi) increases PPAR? acetylation status, activity and expression levels. Therefore, we propose a combination treatment of HDACi and PPAR? agonists as a potential strategy for the treatment of breast cancer.
Appears in Collections:Ph.D Theses (Open)

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