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Title: GDNF Receptor Complex in Neuronal Differentiation and Breast Cancer
Keywords: GDNF, GDNF receptor isoforms, Ntera2, MCF7, neuronal differentiation, breast cancer
Issue Date: 29-Jan-2014
Citation: CHIN MEIYI (2014-01-29). GDNF Receptor Complex in Neuronal Differentiation and Breast Cancer. ScholarBank@NUS Repository.
Abstract: Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) and their receptor complex functions are well-known in neurobiology; and there are increasing evidences showing their involvement in tumour biology. GDNF has been known to induce neuronal stem cell and neuronal progenitor cell survival and differentiation; however, the effect of another GFL, neuturin (NTN) and the specific roles of GDNF receptor (GFR) isoforms are poorly understood. In this study, using an Ntera2 model, we examined the regulation of the GFR system; and the profile of neuronal lineages during differentiation induced by different GFLs. We also examined the roles of specific GFRa1 isoforms and their co-receptor, Ret, which were known to be over-expressed in human breast cancers and promote tumor progression with an MCF7 model. Overall, these studies would provide insights on the roles of GFR systems in neuronal differentiation and their roles in breast cancer progression.
Appears in Collections:Master's Theses (Open)

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