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Title: Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects
Authors: Cheung, C.Y. 
Chen, D.
Wong, T.Y. 
Tham, Y.C.
Wu, R.
Zheng, Y.
Cheng, C.Y. 
Saw, S.M. 
Baskaran, M.
Leung, C.K.
Aung, T.
Issue Date: Dec-2011
Citation: Cheung, C.Y., Chen, D., Wong, T.Y., Tham, Y.C., Wu, R., Zheng, Y., Cheng, C.Y., Saw, S.M., Baskaran, M., Leung, C.K., Aung, T. (2011-12). Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects. Investigative Ophthalmology and Visual Science 52 (13) : 9629-9635. ScholarBank@NUS Repository.
Abstract: Purpose. To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults. Methods. Adults ranging in age from 40 to 80 years were consecutively recruited from the population-based Singapore Chinese Eye Study. A SD-OCT instrument was used to measure ONH and RNFL parameters. A total of 542 eyes from 542 non-glaucomatous Chinese subjects were analyzed. Univariable and multiple linear regression analyses were performed to examine the effects of a range of ocular (e.g., intraocular pressure [IOP], axial length [AL], disc area) and systemic (e.g., blood pressure, serum glucose) factors on ONH and RNFL parameters. Results. In multiple regression analyses, neuroretinal rim area was independently associated with age (β = -0.006, P < 0.001), disc area (β = 0.183, P < 0.001), IOP (β = -0.009, P = 0.008), AL (β = -0.023, P = 0.004), and lens nuclear color (β = 0.042, P = 0.001). Vertical cup-to-disc ratio was independently correlated with age (β = 0.003, P < 0.001), disc area (β = 0.207, P < 0.001), IOP (β = 0.004, P = 0.014), AL (β = 0.010, P = 0.008), and lens nuclear color (β = -0.017, P = 0.006). Average RNFL thickness was independently related to age (β = -0.204, P = 0.001), disc area (β = 4.218, P < 0.001), signal strength (β = 1.348, P < 0.001), and AL (β = -1.332, P < 0.001). Disc area had the strongest effect on measurements of ONH parameters and RNFL thickness. Conclusions. In a non-glaucomatous population, optic nerve measurements with SD-OCT vary with disc area, age, IOP, AL, lens nuclear color, and signal strength, but systemic parameters have little influence. This information may be useful for interpretation of SD-OCT measurements. © 2011 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
ISSN: 01460404
DOI: 10.1167/iovs.11-7481
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