Please use this identifier to cite or link to this item:
https://doi.org/10.1167/iovs.12-10414
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dc.title | Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography | |
dc.contributor.author | Koh, V.T. | |
dc.contributor.author | Tham, Y.-C. | |
dc.contributor.author | Cheung, C.Y. | |
dc.contributor.author | Wong, W.-L. | |
dc.contributor.author | Baskaran, M. | |
dc.contributor.author | Saw, S.-M. | |
dc.contributor.author | Wong, T.Y. | |
dc.contributor.author | Aung, T. | |
dc.date.accessioned | 2014-05-20T02:29:07Z | |
dc.date.available | 2014-05-20T02:29:07Z | |
dc.date.issued | 2012-08 | |
dc.identifier.citation | Koh, V.T., Tham, Y.-C., Cheung, C.Y., Wong, W.-L., Baskaran, M., Saw, S.-M., Wong, T.Y., Aung, T. (2012-08). Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Investigative Ophthalmology and Visual Science 53 (9) : 5853-5859. ScholarBank@NUS Repository. https://doi.org/10.1167/iovs.12-10414 | |
dc.identifier.issn | 01460404 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/53414 | |
dc.description.abstract | Purpose. To determine the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (±SD) age of study subjects was 52.84 ± 6.14 years, 50.1% were male, and all subjects had normal visual fields with no signs of glaucoma or glaucoma suspect. The mean overall, minimum, superior, and inferior GC-IPL thicknesses were 82.78 ± 7.01 μm, 79.67 ± 9.17 μm, 83.30 ± 7.89 μm, and 80.16 ± 8.31 μm, respectively. In multiple linear regression analysis, GC-IPL thickness was significantly associated with age (β = -0.202, P < 0.001), female sex (β = -2.367, P < 0.001), axial length (β = -1.279, P = 0.002), and mean peripapillary retinal nerve fiber layer (RNFL) thickness (β = 0.337, P < 0.001). IOP, central corneal thickness, disc area, serum glucose level, and history of diabetes mellitus had no significant influence on GC-IPL thickness. Conclusions. Thinner GC-IPL was independently associated with older age, female sex, longer axial length, and thinner RNFL thickness. These factors should be taken into account when interpreting GC-IPL thickness measurements with HD-OCT for glaucoma assessment. © 2012 The Association for Research in Vision and Ophthalmology, Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1167/iovs.12-10414 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE | |
dc.contributor.department | SAW SWEE HOCK SCHOOL OF PUBLIC HEALTH | |
dc.contributor.department | OPHTHALMOLOGY | |
dc.description.doi | 10.1167/iovs.12-10414 | |
dc.description.sourcetitle | Investigative Ophthalmology and Visual Science | |
dc.description.volume | 53 | |
dc.description.issue | 9 | |
dc.description.page | 5853-5859 | |
dc.description.coden | IOVSD | |
dc.identifier.isiut | 000308695400096 | |
Appears in Collections: | Staff Publications |
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