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Title: Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography
Authors: Koh, V.T.
Tham, Y.-C.
Cheung, C.Y. 
Wong, W.-L.
Baskaran, M.
Saw, S.-M. 
Wong, T.Y. 
Aung, T.
Issue Date: Aug-2012
Citation: Koh, V.T., Tham, Y.-C., Cheung, C.Y., Wong, W.-L., Baskaran, M., Saw, S.-M., Wong, T.Y., Aung, T. (2012-08). Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Investigative Ophthalmology and Visual Science 53 (9) : 5853-5859. ScholarBank@NUS Repository.
Abstract: Purpose. To determine the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). Methods. Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. Results. The mean (±SD) age of study subjects was 52.84 ± 6.14 years, 50.1% were male, and all subjects had normal visual fields with no signs of glaucoma or glaucoma suspect. The mean overall, minimum, superior, and inferior GC-IPL thicknesses were 82.78 ± 7.01 μm, 79.67 ± 9.17 μm, 83.30 ± 7.89 μm, and 80.16 ± 8.31 μm, respectively. In multiple linear regression analysis, GC-IPL thickness was significantly associated with age (β = -0.202, P < 0.001), female sex (β = -2.367, P < 0.001), axial length (β = -1.279, P = 0.002), and mean peripapillary retinal nerve fiber layer (RNFL) thickness (β = 0.337, P < 0.001). IOP, central corneal thickness, disc area, serum glucose level, and history of diabetes mellitus had no significant influence on GC-IPL thickness. Conclusions. Thinner GC-IPL was independently associated with older age, female sex, longer axial length, and thinner RNFL thickness. These factors should be taken into account when interpreting GC-IPL thickness measurements with HD-OCT for glaucoma assessment. © 2012 The Association for Research in Vision and Ophthalmology, Inc.
Source Title: Investigative Ophthalmology and Visual Science
ISSN: 01460404
DOI: 10.1167/iovs.12-10414
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