Please use this identifier to cite or link to this item:
Title: Therapeutic targets: Progress of their exploration and investigation of their characteristics
Authors: Zheng, C.J. 
Han, L.Y. 
Yap, C.W. 
Ji, Z.L. 
Cao, Z.W. 
Chen, Y.Z. 
Issue Date: Jun-2006
Citation: Zheng, C.J., Han, L.Y., Yap, C.W., Ji, Z.L., Cao, Z.W., Chen, Y.Z. (2006-06). Therapeutic targets: Progress of their exploration and investigation of their characteristics. Pharmacological Reviews 58 (2) : 259-279. ScholarBank@NUS Repository.
Abstract: Modern drug discovery is primarily based on the search and subsequent testing of drug candidates acting on a preselected therapeutic target. Progress in genomics, protein structure, proteomics, and disease mechanisms has led to a growing interest in and effort for finding new targets and more effective exploration of existing targets. The number of reported targets of marketed and investigational drugs has significantly increased in the past 8 years. There are 1535 targets collected in the therapeutic target database compared with ∼500 targets reported in a 1996 review. Knowledge of these targets is helpful for molecular dissection of the mechanism of action of drugs and for predicting features that guide new drug design and the search for new targets. This article summarizes the progress of target exploration and investigates the characteristics of the currently explored targets to analyze their sequence, structure, family representation, pathway association, tissue distribution, and genome location features for finding clues useful for searching for new targets. Possible "rules" to guide the search for druggable proteins and the feasibility of using a statistical learning method for predicting druggable proteins directly from their sequences are discussed. Copyright © 2006 by The American Society for Pharmacology and Experimental Therapeutics.
Source Title: Pharmacological Reviews
ISSN: 00316997
DOI: 10.1124/pr.58.2.4
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jul 2, 2022


checked on Jun 24, 2022

Page view(s)

checked on Jun 23, 2022

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.