Please use this identifier to cite or link to this item: https://doi.org/10.1016/S1359-6446(05)03377-5
DC FieldValue
dc.titleComputer prediction of drug resistance mutations in proteins
dc.contributor.authorCao, Z.W.
dc.contributor.authorHan, L.Y.
dc.contributor.authorZheng, C.J.
dc.contributor.authorJi, Z.L.
dc.contributor.authorChen, X.
dc.contributor.authorLin, H.H.
dc.contributor.authorChen, Y.Z.
dc.date.accessioned2014-05-19T02:57:18Z
dc.date.available2014-05-19T02:57:18Z
dc.date.issued2005-04-01
dc.identifier.citationCao, Z.W., Han, L.Y., Zheng, C.J., Ji, Z.L., Chen, X., Lin, H.H., Chen, Y.Z. (2005-04-01). Computer prediction of drug resistance mutations in proteins. Drug Discovery Today 10 (7) : 521-529. ScholarBank@NUS Repository. https://doi.org/10.1016/S1359-6446(05)03377-5
dc.identifier.issn13596446
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/53341
dc.description.abstractDrug resistance is of increasing concern in the treatment of infectious diseases and cancer. Mutation in drug-interacting disease proteins is one of the primary causes for resistance particularly against anti-infectious drugs. Prediction of resistance mutations in these proteins is valuable both for the molecular dissection of drug resistance mechanisms and for predicting features that guide the design of new agents to counter resistant strains. Several protein structure- and sequence-based computer methods have been explored for mechanistic study and prediction of resistance mutations. These methods and their usefulness are reviewed here. ©2005 Elsevier Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S1359-6446(05)03377-5
dc.sourceScopus
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentCOMPUTATIONAL SCIENCE
dc.description.doi10.1016/S1359-6446(05)03377-5
dc.description.sourcetitleDrug Discovery Today
dc.description.volume10
dc.description.issue7
dc.description.page521-529
dc.description.codenDDTOF
dc.identifier.isiut000227936000013
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