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Title: Risk factors for pandemic (H1N1) 2009 virus seroconversion among hospital staff, Singapore
Authors: Chen, M.I.C. 
Lee, V.J.M.
Barr, I.
Lin, C.
Goh, R.
Lee, C.
Singh, B.
Tan, J.
Lim, W.-Y. 
Cook, A.R. 
Ang, B.
Chow, A.
Tan, B.H. 
Loh, J.
Shaw, R.
Chia, K.S. 
Lin, R.T.P.
Leo, Y.S.
Issue Date: Oct-2010
Citation: Chen, M.I.C., Lee, V.J.M., Barr, I., Lin, C., Goh, R., Lee, C., Singh, B., Tan, J., Lim, W.-Y., Cook, A.R., Ang, B., Chow, A., Tan, B.H., Loh, J., Shaw, R., Chia, K.S., Lin, R.T.P., Leo, Y.S. (2010-10). Risk factors for pandemic (H1N1) 2009 virus seroconversion among hospital staff, Singapore. Emerging Infectious Diseases 16 (10) : 1554-1561. ScholarBank@NUS Repository.
Abstract: We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October2009, with seroconversion defined as a ≥4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009.Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factor son multivariate analysis were being a nurse (adjusted odd sratio [a OR] 4.5, 95% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR4.5, 95% CI 1.3-15.6). Contact with pandemic (H1N1)2009-infected colleagues (a OR 2.5, 95% CI 0.9-6.6) and larger household size (a OR 1.2, 95% CI 1.0-1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.
Source Title: Emerging Infectious Diseases
ISSN: 10806040
DOI: 10.3201/eid1610.100516
Appears in Collections:Staff Publications

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