Please use this identifier to cite or link to this item: https://doi.org/10.1002/cncr.24485
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dc.titlePathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor- extracellular signal-regulated protein kinase pathway at altered protein levels
dc.contributor.authorLi, H.
dc.contributor.authorChoong, Y.U.
dc.contributor.authorXiao, H.M.
dc.contributor.authorXiang, H.L.
dc.contributor.authorBao, W.L.
dc.contributor.authorBoon, C.L.
dc.contributor.authorYu, Z.C.
dc.date.accessioned2014-05-19T02:54:00Z
dc.date.available2014-05-19T02:54:00Z
dc.date.issued2009-09-15
dc.identifier.citationLi, H., Choong, Y.U., Xiao, H.M., Xiang, H.L., Bao, W.L., Boon, C.L., Yu, Z.C. (2009-09-15). Pathway sensitivity analysis for detecting pro-proliferation activities of oncogenes and tumor suppressors of epidermal growth factor receptor- extracellular signal-regulated protein kinase pathway at altered protein levels. Cancer 115 (18) : 4246-4263. ScholarBank@NUS Repository. https://doi.org/10.1002/cncr.24485
dc.identifier.issn0008543X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/53083
dc.description.abstractBACKGROUND: Mathematic models and sensitivity analyses of biologic pathways have been used for exploring the dynamics and for detecting the key components of signaling pathways. METHODS: The authors previously developed a mathematic model of the epidermal growth factor receptor-extracellular signal-regulated protein kinase (EGFR-ERK) pathway using ordinary differential equations from existing EGFR-ERK pathway models. By using prolonged ERK activation as an indicator that may lead to cell proliferation under certain circumstances, in the current study, a pathway sensitivity analysis was performed to test its capability of detecting pro-proliferative activities through altered protein levels to examine the effects on ERK activation. RESULTS: The analysis revealed that 12 of 20 oncoproteins and 4 of 5 tumor suppressors were detected, consistent with reported experimental works. Because pathway dynamics depend on many factors, some of which were not included in the current models, failure to detect all known oncogenes and tumor suppressors can be because of the failure to include relevant crosstalk to other pathway components. CONCLUSIONS: Overall, the current results indicated that pathway sensitivity analysis is a useful approach for detecting and distinguishing pro-proliferation activities of oncoproteins and suppressed proliferative activities of tumor suppressors at altered protein levels at least in the EGFR-ERK model. © 2009 American Cancer Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/cncr.24485
dc.sourceScopus
dc.subjectBiologic networks
dc.subjectEpidermal growth factor receptor-extracellular signal-regulated protein kinase pathway
dc.subjectOncogene
dc.subjectPathway simulation
dc.subjectSystem biology
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.contributor.departmentPHYSICS
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.doi10.1002/cncr.24485
dc.description.sourcetitleCancer
dc.description.volume115
dc.description.issue18
dc.description.page4246-4263
dc.description.codenCANCA
dc.identifier.isiut000269709300027
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