Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cell.2011.11.050
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dc.titleGlycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis
dc.contributor.authorZhang, W.C.
dc.contributor.authorNg, S.-C.
dc.contributor.authorYang, H.
dc.contributor.authorRai, A.
dc.contributor.authorUmashankar, S.
dc.contributor.authorMa, S.
dc.contributor.authorSoh, B.S.
dc.contributor.authorSun, L.L.
dc.contributor.authorTai, B.C.
dc.contributor.authorNga, M.E.
dc.contributor.authorBhakoo, K.K.
dc.contributor.authorJayapal, S.R.
dc.contributor.authorNichane, M.
dc.contributor.authorYu, Q.
dc.contributor.authorAhmed, D.A.
dc.contributor.authorTan, C.
dc.contributor.authorSing, W.P.
dc.contributor.authorTam, J.
dc.contributor.authorThirugananam, A.
dc.contributor.authorNoghabi, M.S.
dc.contributor.authorPang, Y.H.
dc.contributor.authorAng, H.S.
dc.contributor.authorRobson, P.
dc.contributor.authorKaldis, P.
dc.contributor.authorSoo, R.A.
dc.contributor.authorSwarup, S.
dc.contributor.authorLim, E.H.
dc.contributor.authorLim, B.
dc.date.accessioned2014-05-19T02:52:26Z
dc.date.available2014-05-19T02:52:26Z
dc.date.issued2012-01-20
dc.identifier.citationZhang, W.C., Ng, S.-C., Yang, H., Rai, A., Umashankar, S., Ma, S., Soh, B.S., Sun, L.L., Tai, B.C., Nga, M.E., Bhakoo, K.K., Jayapal, S.R., Nichane, M., Yu, Q., Ahmed, D.A., Tan, C., Sing, W.P., Tam, J., Thirugananam, A., Noghabi, M.S., Pang, Y.H., Ang, H.S., Robson, P., Kaldis, P., Soo, R.A., Swarup, S., Lim, E.H., Lim, B. (2012-01-20). Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis. Cell 148 (1-2) : 259-272. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cell.2011.11.050
dc.identifier.issn00928674
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52967
dc.description.abstractIdentification of the factors critical to the tumor-initiating cell (TIC) state may open new avenues in cancer therapy. Here we show that the metabolic enzyme glycine decarboxylase (GLDC) is critical for TICs in non-small cell lung cancer (NSCLC). TICs from primary NSCLC tumors express high levels of the oncogenic stem cell factor LIN28B and GLDC, which are both required for TIC growth and tumorigenesis. Overexpression of GLDC and other glycine/serine enzymes, but not catalytically inactive GLDC, promotes cellular transformation and tumorigenesis. We found that GLDC induces dramatic changes in glycolysis and glycine/serine metabolism, leading to changes in pyrimidine metabolism to regulate cancer cell proliferation. In the clinic, aberrant activation of GLDC correlates with poorer survival in lung cancer patients, and aberrant GLDC expression is observed in multiple cancer types. This link between glycine metabolism and tumorigenesis may provide novel targets for advancing anticancer therapy. © 2012 Elsevier Inc.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.cell.2011.11.050
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1016/j.cell.2011.11.050
dc.description.sourcetitleCell
dc.description.volume148
dc.description.issue1-2
dc.description.page259-272
dc.description.codenCELLB
dc.identifier.isiut000299540700029
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