Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0027819
DC FieldValue
dc.titleExistence of inverted profile in chemically responsive molecular pathways in the zebrafish liver
dc.contributor.authorUng, C.Y.
dc.contributor.authorLam, S.H.
dc.contributor.authorZhang, X.
dc.contributor.authorLi, H.
dc.contributor.authorMa, J.
dc.contributor.authorZhang, L.
dc.contributor.authorLi, B.
dc.contributor.authorGong, Z.
dc.date.accessioned2014-05-19T02:51:53Z
dc.date.available2014-05-19T02:51:53Z
dc.date.issued2011-11-29
dc.identifier.citationUng, C.Y., Lam, S.H., Zhang, X., Li, H., Ma, J., Zhang, L., Li, B., Gong, Z. (2011-11-29). Existence of inverted profile in chemically responsive molecular pathways in the zebrafish liver. PLoS ONE 6 (11) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0027819
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52924
dc.description.abstractHow a living organism maintains its healthy equilibrium in response to endless exposure of potentially harmful chemicals is an important question in current biology. By transcriptomic analysis of zebrafish livers treated by various chemicals, we defined hubs as molecular pathways that are frequently perturbed by chemicals and have high degree of functional connectivity to other pathways. Our network analysis revealed that these hubs were organized into two groups showing inverted functionality with each other. Intriguingly, the inverted activity profiles in these two groups of hubs were observed to associate only with toxicopathological states but not with physiological changes. Furthermore, these inverted profiles were also present in rat, mouse, and human under certain toxicopathological conditions. Thus, toxicopathological-associated anti-correlated profiles in hubs not only indicate their potential use in diagnosis but also development of systems-based therapeutics to modulate gene expression by chemical approach in order to rewire the deregulated activities of hubs back to normal physiology. © 2011 Ung et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0027819
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentPHYSICS
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentMATHEMATICS
dc.description.doi10.1371/journal.pone.0027819
dc.description.sourcetitlePLoS ONE
dc.description.volume6
dc.description.issue11
dc.description.page-
dc.identifier.isiut000298166300011
Appears in Collections:Staff Publications
Elements

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
2011-existence_inverted_profile_chemically_responsive-pub.pdf1.3 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

9
checked on Nov 29, 2021

WEB OF SCIENCETM
Citations

10
checked on Nov 22, 2021

Page view(s)

321
checked on Nov 18, 2021

Download(s)

13
checked on Nov 18, 2021

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.