Please use this identifier to cite or link to this item: https://doi.org/10.1086/656480
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dc.titleEffectiveness of public health measures in mitigating pandemic influenza spread: A prospective sero-epidemiological cohort study
dc.contributor.authorLee, V.J.
dc.contributor.authorYap, J.
dc.contributor.authorCook, A.R.
dc.contributor.authorChen, M.I.
dc.contributor.authorTay, J.K.
dc.contributor.authorBarr, I.
dc.contributor.authorKelso, A.
dc.contributor.authorTan, B.H.
dc.contributor.authorLoh, J.P.
dc.contributor.authorLin, R.
dc.contributor.authorCui, L.
dc.contributor.authorKelly, P.M.
dc.contributor.authorLeo, Y.S.
dc.contributor.authorChia, K.S.
dc.contributor.authorKang, W.L.
dc.contributor.authorTambyah, P.A.
dc.contributor.authorSeet, B.
dc.date.accessioned2014-05-19T02:51:31Z
dc.date.available2014-05-19T02:51:31Z
dc.date.issued2010-11-01
dc.identifier.citationLee, V.J., Yap, J., Cook, A.R., Chen, M.I., Tay, J.K., Barr, I., Kelso, A., Tan, B.H., Loh, J.P., Lin, R., Cui, L., Kelly, P.M., Leo, Y.S., Chia, K.S., Kang, W.L., Tambyah, P.A., Seet, B. (2010-11-01). Effectiveness of public health measures in mitigating pandemic influenza spread: A prospective sero-epidemiological cohort study. Journal of Infectious Diseases 202 (9) : 1319-1326. ScholarBank@NUS Repository. https://doi.org/10.1086/656480
dc.identifier.issn00221899
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52893
dc.description.abstractBackground. Few studies have validated the effectiveness of public health interventions in reducing influenza spread in real-life settings. We aim to validate these measures used during the 2009 pandemic. Methods. From 22 June to 9 October 2009, we performed a prospective observational cohort study using paired serum samples and symptom review among 3 groups of Singapore military personnel. "Normal" units were subjected to prevailing pandemic response policies. "Essential" units and health care workers had additional public health interventions (eg, enhanced surveillance with isolation, segregation, personal protective equipment). Samples were tested by hemagglutination inhibition; the principal outcome was seroconversion to 2009 influenza A(H1N1). Results. In total, 1015 individuals in 14 units completed the study, with 29% overall seroconversion. Seroconversion among essential units (17%) and health care workers (11%) was significantly lower than that in normal units (44%) (P < .001). Symptomatic illness attributable to influenza was also lower in essential units (5%) and health care workers (2%) than in normal units (12%) (P = .06). Adjusted for confounders, unit type was the only significant variable influencing overall seroconversion (P < .05). From multivariate analysis within each unit, age (P < .001) and baseline antibody titer (P = .012) were inversely related to seroconversion risk. Conclusions. Public health measures are effective in limiting influenza transmission in closed environments. © 2010 by the Infectious Diseases Society of America. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1086/656480
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSTATISTICS & APPLIED PROBABILITY
dc.contributor.departmentEPIDEMIOLOGY & PUBLIC HEALTH
dc.contributor.departmentDUKE-NUS GRADUATE MEDICAL SCHOOL S'PORE
dc.description.doi10.1086/656480
dc.description.sourcetitleJournal of Infectious Diseases
dc.description.volume202
dc.description.issue9
dc.description.page1319-1326
dc.description.codenJIDIA
dc.identifier.isiut000282367900005
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