Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1365-2265.2012.04480.x
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dc.titleAssociations between complications and health-related quality of life in individuals with diabetes
dc.contributor.authorVenkataraman K.
dc.contributor.authorWee H.L.
dc.contributor.authorLeow M.K.S.
dc.contributor.authorTai E.S.
dc.contributor.authorLee J.
dc.contributor.authorLim S.C.
dc.contributor.authorTavintharan S.
dc.contributor.authorWong T.Y.
dc.contributor.authorMa S.
dc.contributor.authorHeng D.
dc.contributor.authorThumboo J.
dc.date.accessioned2014-05-19T02:50:13Z
dc.date.available2014-05-19T02:50:13Z
dc.date.issued2013-06
dc.identifier.citationVenkataraman K., Wee H.L., Leow M.K.S., Tai E.S., Lee J., Lim S.C., Tavintharan S., Wong T.Y., Ma S., Heng D., Thumboo J. (2013-06). Associations between complications and health-related quality of life in individuals with diabetes. Clinical Endocrinology 78 (6) : 865-873. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1365-2265.2012.04480.x
dc.identifier.issn03000664
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52799
dc.description.abstractObjective Type 2 diabetes and associated complications adversely affect health-related quality of life (HRQoL). However, it is unclear whether different complications have the same or different associations with HRQoL. We examined associations between retinopathy, nephropathy, peripheral neuropathy (microvascular), coronary heart disease, stroke and peripheral arterial disease (macrovascular) in diabetes and HRQoL. Design This study was a follow-up examination between 2004 and 2007 of participants from four previous cross-sectional population-based studies in Singapore. Methods Health-related quality of life was assessed through self-administered SF-36 health survey version 2. Diabetes and complications status were assessed through self-report, clinical and laboratory examinations. About 2601 individuals, 2205 healthy and 396 with diabetes, were studied. Results Lower physical component scores (PCS) were associated with microvascular (2·96 points, P < 0·001) and both macro- and microvascular complications (4·67 points, P < 0·001), but not diabetes alone. Coronary heart disease (3·86 points, P = 0·007), peripheral neuropathy (11·46 points, P < 0·001) and severe retinopathy (4·46 points, P < 0·001) were associated with lower PCS. The greatest reduction in scores was seen in peripheral neuropathy. Conclusions Quality of life in patients with diabetes is affected mainly by presence of complications, and not diabetes per se. Peripheral neuropathy was associated with the greatest reduction in quality of life. Improved management to prevent or delay onset of complications may reduce the effect on quality of life in patients with diabetes. © 2012 John Wiley & Sons Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/j.1365-2265.2012.04480.x
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentDUKE-NUS MEDICAL SCHOOL
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentDEPT OF PHARMACY
dc.contributor.departmentDEPT OF MEDICINE
dc.contributor.departmentDEAN'S OFFICE (SSH SCH OF PUBLIC HEALTH)
dc.description.doi10.1111/j.1365-2265.2012.04480.x
dc.description.sourcetitleClinical Endocrinology
dc.description.volume78
dc.description.issue6
dc.description.page865-873
dc.description.codenCLENA
dc.identifier.isiut000318110800010
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