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Title: Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography
Authors: Ching, C.B. 
Lim, B.G. 
Lee, E.J.D.
Ng, S.C. 
Issue Date: 1993
Citation: Ching, C.B., Lim, B.G., Lee, E.J.D., Ng, S.C. (1993). Preparative resolution of praziquantel enantiomers by simulated counter-current chromatography. Journal of Chromatography 634 (2) : 215-219. ScholarBank@NUS Repository.
Abstract: The continuous chromatographic separation of a racemic anthelmintic drug, praziquantel, was carried out using a simulated counter-current system. The system consists of four identical columns (445 mm x 12.5 mm I.D.) connected in series through solenoid valves. The chiral stationary phase used is microcrystalline cellulose triacetate and the eluent is methanol. Feed at 50 mg/ml was continuously introduced into the system at 0.3 ml/min and 429 mg/h of (+)-praziquantel and 404 mg/h of (-)-praziquantel were obtained from the extract and raffinate streams, respectively. The optical purity of the products was more than 90%. This method provides an extremely useful technique for preparative-scale enantioseparation. Compared with conventional batch preparative-scale processes, this system offers a higher solute to adsorbent mass ratio.
Source Title: Journal of Chromatography
ISSN: 00219673
DOI: 10.1016/0021-9673(93)83007-F
Appears in Collections:Staff Publications

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