Please use this identifier to cite or link to this item: https://doi.org/10.1021/bm0611533
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dc.titleResponse of cells on surface-induced nanopatterns: Fibroblasts and mesenchymal progenitor cells
dc.contributor.authorKhor, H.L.
dc.contributor.authorKuan, Y.
dc.contributor.authorKukula, H.
dc.contributor.authorTamada, K.
dc.contributor.authorKnoll, W.
dc.contributor.authorMoeller, M.
dc.contributor.authorHutmacher, D.W.
dc.date.accessioned2014-05-16T04:59:04Z
dc.date.available2014-05-16T04:59:04Z
dc.date.issued2007-05
dc.identifier.citationKhor, H.L., Kuan, Y., Kukula, H., Tamada, K., Knoll, W., Moeller, M., Hutmacher, D.W. (2007-05). Response of cells on surface-induced nanopatterns: Fibroblasts and mesenchymal progenitor cells. Biomacromolecules 8 (5) : 1530-1540. ScholarBank@NUS Repository. https://doi.org/10.1021/bm0611533
dc.identifier.issn15257797
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52549
dc.description.abstractUltrathin films of a poly(styrene)-block-poly(2-vinylpyrindine) diblock copolymer (PS-b-P2VP) and poly(styrene)-block-poly(4-vinylpyrindine) diblock copolymer (PS-b-P4VP) were used to form surface-induced nanopattern (SINPAT) on mica. Surface interaction controlled microphase separation led to the formation of chemically heterogeneous surface nanopatterns on dry ultrathin films. Two distinct nanopatterned surfaces, namely, wormlike and dotlike patterns, were used to investigate the influence of topography in the nanometer range on cell adhesion, proliferation, and migration. Atomic force microscopy was used to confirm that SINPAT was stable under cell culture conditions. Fibroblasts and mesenchymal progenitor cells were cultured on the nanopatterned surfaces. Phase contrast and confocal laser microscopy showed that fibroblasts and mesenchymal progenitor cells preferred the densely spaced wormlike patterns. Atomic force microscopy showed that the cells remodelled the extracellular matrix differently as they migrate over the two distinctly different nanopatterns. © 2007 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/bm0611533
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentBIOENGINEERING
dc.contributor.departmentCHEMISTRY
dc.description.doi10.1021/bm0611533
dc.description.sourcetitleBiomacromolecules
dc.description.volume8
dc.description.issue5
dc.description.page1530-1540
dc.description.codenBOMAF
dc.identifier.isiut000246413600021
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