Please use this identifier to cite or link to this item: https://doi.org/10.1371/journal.pone.0047816
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dc.titlePopulation Differences in Brain Morphology and Microstructure among Chinese, Malay, and Indian Neonates
dc.contributor.authorBai, J.
dc.contributor.authorAbdul-Rahman, M.F.
dc.contributor.authorRifkin-Graboi, A.
dc.contributor.authorChong, Y.-S.
dc.contributor.authorKwek, K.
dc.contributor.authorSaw, S.-M.
dc.contributor.authorGodfrey, K.M.
dc.contributor.authorGluckman, P.D.
dc.contributor.authorFortier, M.V.
dc.contributor.authorMeaney, M.J.
dc.contributor.authorQiu, A.
dc.date.accessioned2014-05-16T04:58:55Z
dc.date.available2014-05-16T04:58:55Z
dc.date.issued2012-10-24
dc.identifier.citationBai, J., Abdul-Rahman, M.F., Rifkin-Graboi, A., Chong, Y.-S., Kwek, K., Saw, S.-M., Godfrey, K.M., Gluckman, P.D., Fortier, M.V., Meaney, M.J., Qiu, A. (2012-10-24). Population Differences in Brain Morphology and Microstructure among Chinese, Malay, and Indian Neonates. PLoS ONE 7 (10) : -. ScholarBank@NUS Repository. https://doi.org/10.1371/journal.pone.0047816
dc.identifier.issn19326203
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/52543
dc.description.abstractWe studied a sample of 75 Chinese, 73 Malay, and 29 Indian healthy neonates taking part in a cohort study to examine potential differences in neonatal brain morphology and white matter microstructure as a function of ethnicity using both structural T2-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). We first examined the differences in global size and morphology of the brain among the three groups. We then constructed the T2-weighted MRI and DTI atlases and employed voxel-based analysis to investigate ethnic differences in morphological shape of the brain from the T2-weighted MRI, and white matter microstructure measured by fractional anisotropy derived from DTI. Compared with Malay neonates, the brains of Indian neonates' tended to be more elongated in anterior and posterior axis relative to the superior-inferior axis of the brain even though the total brain volume was similar among the three groups. Although most anatomical regions of the brain were similar among Chinese, Malay, and Indian neonates, there were anatomical variations in the spinal-cerebellar and cortical-striatal-thalamic neural circuits among the three populations. The population-related brain regions highlighted in our study are key anatomical substrates associated with sensorimotor functions. © 2012 Bai et al.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1371/journal.pone.0047816
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSAW SWEE HOCK SCHOOL OF PUBLIC HEALTH
dc.contributor.departmentBIOENGINEERING
dc.description.doi10.1371/journal.pone.0047816
dc.description.sourcetitlePLoS ONE
dc.description.volume7
dc.description.issue10
dc.description.page-
dc.identifier.isiut000310310200085
dc.description.seriesGUSTO (Growing up towards Healthy Outcomes)
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