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|Title:||INVESTIGATIONS OF ANTI-INFLAMMATORY MECHANISMS OF ANTI-MALARIAL DRUG ARTESUNATE IN ALLERGIC ASTHMA||Authors:||HO WANXING EUGENE||Keywords:||Artemisinin, Oxidative Stress, Mass Spectrometry, Metabolomics, Bronchoalveolar lavage fluid, Nuclear factor (erythroid-derived 2)-like 2||Issue Date:||8-Jan-2014||Citation:||HO WANXING EUGENE (2014-01-08). INVESTIGATIONS OF ANTI-INFLAMMATORY MECHANISMS OF ANTI-MALARIAL DRUG ARTESUNATE IN ALLERGIC ASTHMA. ScholarBank@NUS Repository.||Abstract:||Artesunate is an anti-malarial drug with promising anti-inflammatory effects in allergic asthma. We investigated the protective effects of artesunate in experimental allergic asthma, in comparison to corticosteroids, dexamethasone. We demonstrate that artesunate possess favourable pharmacological effects against oxidative lung damage markers, 8-isoprostane, 3-nitrotyrosine and 8-hydroxy-2-deoxyguanosine. These effects include modulation of pulmonary antioxidants (catalase and SOD) and broad suppression of pulmonary pro-oxidants (NADPH oxidases and iNOS), via promotion of nuclear Nrf2 levels. Correspondingly, metabolomics was employed understand altered pulmonary metabolism and the protective effects of artesunate in allergic asthma. Liquid and gas chromatography mass spectrometry (LC/MS & GC/MS) were employed to investigate bronchoalveolar lavage fluid and serum of experimental allergic asthma with artesunate treatment. Our results reveal that artesunate can reverse disease-associated metabolite changes in allergic asthma, especially alterations in the lipid, sterol, carbohydrates and energy metabolism. Collectively, our findings implicate therapeutic values of using artesunate in treating allergic asthma.||URI:||http://scholarbank.nus.edu.sg/handle/10635/51992|
|Appears in Collections:||Ph.D Theses (Open)|
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