Please use this identifier to cite or link to this item: https://doi.org/10.1002/jps.20211
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dc.titleStructural characterization and enantioseparation of the chiral compound praziquantel
dc.contributor.authorLiu, Y.
dc.contributor.authorWang, X.
dc.contributor.authorWang, J.-K.
dc.contributor.authorChing, C.B.
dc.date.accessioned2014-04-25T09:05:25Z
dc.date.available2014-04-25T09:05:25Z
dc.date.issued2004-12
dc.identifier.citationLiu, Y., Wang, X., Wang, J.-K., Ching, C.B. (2004-12). Structural characterization and enantioseparation of the chiral compound praziquantel. Journal of Pharmaceutical Sciences 93 (12) : 3039-3046. ScholarBank@NUS Repository. https://doi.org/10.1002/jps.20211
dc.identifier.issn00223549
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/51819
dc.description.abstractIn this study, we aimed to characterize the chiral compound type of a leading antischistosomal drug, praziquantel. The optically pure praziquantel enantiomers were recovered from the racemic mixture by enantiomeric separation, which was performed on preparative scale chromatography by using a novel β-cyclodextrin type chiral column. The thermodynamic properties of praziquantel were determined from differential scanning calorimetry and the physical properties were studied by examining Fourier transform infrared spectroscopy and X-ray powder diffraction. Based on the differential scanning calorimetry data, a melting point binary phase diagram was constructed. A ternary solubility phase diagram of praziquantel in methanol was also determined at the temperature of 0°C. All the experimental results support the conclusion that praziquantel is a racemic compound. The characterization of physical properties of praziquantel and the phase diagram are crucial for understanding the rationality for the successful resolution of praziquantel and also provide the basis for designing the strategy of separation and recovery of pure enantiomer. © 2004 Wiley-Liss, Inc. and the American Pharmacists Association.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jps.20211
dc.sourceScopus
dc.subjectCalorimetry (DSC)
dc.subjectChromatography
dc.subjectCrystallization
dc.subjectFTIR
dc.subjectX-ray powder diffractometry
dc.typeArticle
dc.contributor.departmentCHEMICAL & BIOMOLECULAR ENGINEERING
dc.contributor.departmentCHEMICAL AND PROCESS ENGINEERING CENTRE
dc.description.doi10.1002/jps.20211
dc.description.sourcetitleJournal of Pharmaceutical Sciences
dc.description.volume93
dc.description.issue12
dc.description.page3039-3046
dc.description.codenJPMSA
dc.identifier.isiut000225520200017
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