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Title: In vitro physical and mechano-chemical properties of biodegradable scaffolds fabricated with PCL and PCL-PEG
Authors: Hoque, M.E.
Feng, W. 
Wong, Y.S. 
Hutmacher, D.W.
Li, S.
Huang, M.H.
Vert, M.
Keywords: Biodegradable
Rapid Prototyping
Issue Date: 2008
Citation: Hoque, M.E.,Feng, W.,Wong, Y.S.,Hutmacher, D.W.,Li, S.,Huang, M.H.,Vert, M. (2008). In vitro physical and mechano-chemical properties of biodegradable scaffolds fabricated with PCL and PCL-PEG. IFMBE Proceedings 21 IFMBE (1) : 821-824. ScholarBank@NUS Repository.
Abstract: Polycaprolactone (PCL) and PCL-based copolymers have shown high potential for drug delivery and tissue engineering applications as degradable biomaterials. However, the degradation of PCL and its copolymers has been reported mostly in the form of films, microspheres and rods for drug delivery devices but not much in the form of scaffolds for tissue engineering applications. The study focuses on the in vitro degradation of scaffolds fabricated with PCL homopolymer and PCL-PEG (polycaprolactone-polyethylene glycol) diblock copolymer using desktop robot-based rapid prototyping (DRBRP) technique. Accelerated degradation was carried out in concentrated NaOH solution to investigate the influence of polymer nature and scaffold architecture on the degradation behavior and kinetics of the scaffolds. Both PCL and PCL-PEG scaffolds realized homogeneous hydrolytic degradation resulting in a consistent molecular weight and mass loss. The consistent material loss caused uniform increase in porosity that decreased the mechanical properties correspondingly. The results suggest that the incorporation of hydrophilic PEG into hydrophobic PCL enhanced the overall hydrophilicity and thus degradability of PCL-PEG copolymer. However, the architectural variation did not influence the degradation kinetics significantly. © 2008 Springer-Verlag.
Source Title: IFMBE Proceedings
ISBN: 9783540691389
ISSN: 16800737
DOI: 10.1007/978-3-540-69139-6-204
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