Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jns.2012.07.034
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dc.titleChanges in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: A pilot study
dc.contributor.authorDong, Y.
dc.contributor.authorTeoh, H.L.
dc.contributor.authorChan, B.P.L.
dc.contributor.authorNing, C.
dc.contributor.authorYeo, T.T.
dc.contributor.authorSinha, A.K.
dc.contributor.authorVenketasubramanian, N.
dc.contributor.authorSlavin, M.J.
dc.contributor.authorSachdev, P.
dc.contributor.authorCollinson, S.L.
dc.contributor.authorChen, C.
dc.contributor.authorSharma, V.K.
dc.date.accessioned2014-04-03T05:21:02Z
dc.date.available2014-04-03T05:21:02Z
dc.date.issued2012-11-15
dc.identifier.citationDong, Y., Teoh, H.L., Chan, B.P.L., Ning, C., Yeo, T.T., Sinha, A.K., Venketasubramanian, N., Slavin, M.J., Sachdev, P., Collinson, S.L., Chen, C., Sharma, V.K. (2012-11-15). Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: A pilot study. Journal of the Neurological Sciences 322 (1-2) : 112-116. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jns.2012.07.034
dc.identifier.issn0022510X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/49981
dc.description.abstractBackground: The direct impact of external carotid-internal carotid (EC-IC) bypass surgery on cognition of patients with severe steno-occlusive disease of internal carotid (ICA) or middle cerebral artery (MCA) is unknown. In this pilot study, we evaluated changes in cerebral hemodynamic and cognition in these patients. Methods: Patients with severe steno-occlusive disease and impaired cerebral vasodilatory reserve (CVR) with transcranial Doppler (TCD) breath holding index (BHI) and acetazolamide-challenged HMPAO-Single Photon Emission Tomographic (SPECT) imaging were offered EC-IC bypass surgery. CVR and cognitive performance using a formal neuropsychological battery were evaluated before and 3-6 months after surgery. Results: Nine patients and 9 matched controls were recruited. Significant CVR improvement from TCD-BHI [median 0 (Inter-quartile range IQR 0.45) to 1.10 (IQR 0.73), p < 0.001] and SPECT (p < 0.001) was observed in surgery patients. EC-IC bypass patients had significant improvement in verbal memory (p = 0.037) and executive function (p = 0.043) and a trend of improvement in visual memory (p = 0.052) compared to controls. Conclusion: EC-IC bypass surgery in carefully selected patients could improve cerebral hemodynamics and verbal memory and executive function. © 2012 Elsevier B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.jns.2012.07.034
dc.sourceScopus
dc.subjectCerebral hemodynamics
dc.subjectCognition
dc.subjectExternal carotid-internal carotid (EC/IC) bypass surgery
dc.subjectIntracranial stenosis
dc.subjectSPECT
dc.subjectTranscranial Doppler
dc.typeArticle
dc.contributor.departmentPSYCHOLOGY
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentMEDICINE
dc.contributor.departmentDIAGNOSTIC RADIOLOGY
dc.description.doi10.1016/j.jns.2012.07.034
dc.description.sourcetitleJournal of the Neurological Sciences
dc.description.volume322
dc.description.issue1-2
dc.description.page112-116
dc.description.codenJNSCA
dc.identifier.isiut000310819500024
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