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|Title:||Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: A pilot study||Authors:||Dong, Y.
External carotid-internal carotid (EC/IC) bypass surgery
|Issue Date:||15-Nov-2012||Citation:||Dong, Y., Teoh, H.L., Chan, B.P.L., Ning, C., Yeo, T.T., Sinha, A.K., Venketasubramanian, N., Slavin, M.J., Sachdev, P., Collinson, S.L., Chen, C., Sharma, V.K. (2012-11-15). Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: A pilot study. Journal of the Neurological Sciences 322 (1-2) : 112-116. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jns.2012.07.034||Abstract:||Background: The direct impact of external carotid-internal carotid (EC-IC) bypass surgery on cognition of patients with severe steno-occlusive disease of internal carotid (ICA) or middle cerebral artery (MCA) is unknown. In this pilot study, we evaluated changes in cerebral hemodynamic and cognition in these patients. Methods: Patients with severe steno-occlusive disease and impaired cerebral vasodilatory reserve (CVR) with transcranial Doppler (TCD) breath holding index (BHI) and acetazolamide-challenged HMPAO-Single Photon Emission Tomographic (SPECT) imaging were offered EC-IC bypass surgery. CVR and cognitive performance using a formal neuropsychological battery were evaluated before and 3-6 months after surgery. Results: Nine patients and 9 matched controls were recruited. Significant CVR improvement from TCD-BHI [median 0 (Inter-quartile range IQR 0.45) to 1.10 (IQR 0.73), p < 0.001] and SPECT (p < 0.001) was observed in surgery patients. EC-IC bypass patients had significant improvement in verbal memory (p = 0.037) and executive function (p = 0.043) and a trend of improvement in visual memory (p = 0.052) compared to controls. Conclusion: EC-IC bypass surgery in carefully selected patients could improve cerebral hemodynamics and verbal memory and executive function. © 2012 Elsevier B.V.||Source Title:||Journal of the Neurological Sciences||URI:||http://scholarbank.nus.edu.sg/handle/10635/49981||ISSN:||0022510X||DOI:||10.1016/j.jns.2012.07.034|
|Appears in Collections:||Staff Publications|
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