Please use this identifier to cite or link to this item:
|Title:||Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: A pilot study||Authors:||Dong, Y.
External carotid-internal carotid (EC/IC) bypass surgery
|Issue Date:||15-Nov-2012||Citation:||Dong, Y., Teoh, H.L., Chan, B.P.L., Ning, C., Yeo, T.T., Sinha, A.K., Venketasubramanian, N., Slavin, M.J., Sachdev, P., Collinson, S.L., Chen, C., Sharma, V.K. (2012-11-15). Changes in cerebral hemodynamic and cognitive parameters after external carotid-internal carotid bypass surgery in patients with severe steno-occlusive disease: A pilot study. Journal of the Neurological Sciences 322 (1-2) : 112-116. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jns.2012.07.034||Abstract:||Background: The direct impact of external carotid-internal carotid (EC-IC) bypass surgery on cognition of patients with severe steno-occlusive disease of internal carotid (ICA) or middle cerebral artery (MCA) is unknown. In this pilot study, we evaluated changes in cerebral hemodynamic and cognition in these patients. Methods: Patients with severe steno-occlusive disease and impaired cerebral vasodilatory reserve (CVR) with transcranial Doppler (TCD) breath holding index (BHI) and acetazolamide-challenged HMPAO-Single Photon Emission Tomographic (SPECT) imaging were offered EC-IC bypass surgery. CVR and cognitive performance using a formal neuropsychological battery were evaluated before and 3-6 months after surgery. Results: Nine patients and 9 matched controls were recruited. Significant CVR improvement from TCD-BHI [median 0 (Inter-quartile range IQR 0.45) to 1.10 (IQR 0.73), p < 0.001] and SPECT (p < 0.001) was observed in surgery patients. EC-IC bypass patients had significant improvement in verbal memory (p = 0.037) and executive function (p = 0.043) and a trend of improvement in visual memory (p = 0.052) compared to controls. Conclusion: EC-IC bypass surgery in carefully selected patients could improve cerebral hemodynamics and verbal memory and executive function. © 2012 Elsevier B.V.||Source Title:||Journal of the Neurological Sciences||URI:||http://scholarbank.nus.edu.sg/handle/10635/49981||ISSN:||0022510X||DOI:||10.1016/j.jns.2012.07.034|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Aug 5, 2020
WEB OF SCIENCETM
checked on Aug 5, 2020
checked on Aug 3, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.