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Title: Chemically-Modified Co-Substituted Hydroxyapatite Nanomaterial for Biomedical Applications
Keywords: antibacterial, bioactivtiy, hydroxyapatite, silicon, silver, substitution
Issue Date: 19-Dec-2013
Citation: LIM POON NIAN (2013-12-19). Chemically-Modified Co-Substituted Hydroxyapatite Nanomaterial for Biomedical Applications. ScholarBank@NUS Repository.
Abstract: Silver, silicon co-substituted hydroxyapatite (Ag,Si-HA) is a novel bi-functional bone graft material that possesses antibacterial and enhanced biological properties, to facilitate bone healing. A phase-pure apatite containing 0.5 wt.% of silver and 0.7 wt.% of silicon, with a bone-mimicking morphology (60 nm x 10 nm) was synthesised. Silver ions of Ag,Si-HA was first reported to diffuse towards the crystal surface, and interact with adherent Staphylococcus aureus, inhibiting its replication for 7 days. In addition, human adipose-derived mesenchymal stem cells proliferated well on Ag,Si-HA, which in turn permitted greater bone differentiation as compared to HA from day 14 onwards. All these results demonstrated that the approach of co-substituting silver and silicon could complement their functions in apatite. This study reports on the synthesis of Ag,Si-HA, evaluates on its physicochemical properties, and synergistic effect of antibacterial action and biological response. In addition, the mechanism of antibacterial action of Ag,Si-HA will also be investigated.
Appears in Collections:Ph.D Theses (Open)

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