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https://scholarbank.nus.edu.sg/handle/10635/49413
DC Field | Value | |
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dc.title | Composite Controlled Release System of Nitric Oxide for Cardiovascular Tissue Engineering Application | |
dc.contributor.author | ZHANG QINYUAN | |
dc.date.accessioned | 2014-02-28T18:02:09Z | |
dc.date.available | 2014-02-28T18:02:09Z | |
dc.date.issued | 2013-09-27 | |
dc.identifier.citation | ZHANG QINYUAN (2013-09-27). Composite Controlled Release System of Nitric Oxide for Cardiovascular Tissue Engineering Application. ScholarBank@NUS Repository. | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/49413 | |
dc.description.abstract | Current synthetic vascular grafts for the reconstructive bypass surgeries face the problem of post-surgery restenosis. Localised sustained release of nitric oxide (NO) is a promising strategy to prevent restenotic events such as vascular smooth muscle cells (vSMCs) over-proliferation, and promote the healing of injured endothelial layer. In this project, a composite controlled release system of NO was developed as a potential material for synthetic vascular grafts via the integration of NO-releasing nanoparticle, hydrogel and polymeric film. A new NO-releasing gelatin-siloxane nanoparticle (GS-NO NP) was developed via S-nitrosothiol modification with good NO-releasing property and excellent cytocompatibility. The potential of freeze-thawed poly(vinyl alcohol) (FT-PVA) hydrogels as carriers for GS-NO NP was evaluated from their property changes with nanoparticle addition, suggesting single FT-PVA hydrogel system might be suitable for applications with moderate addition of GS-NO NPs to maintain their hydrogel properties. GS-NO NP-doped PVA hydrogels were further integrated with biaxial stretched poly(e-caprolactone) films (?PCL) using electrospinning and freezing-thawing (F/T) technique. The integrated composite release system of NO (PCL/PVA/GS-NO) exhibited prolonged NO release for up to 40 days, and enhanced mechanical properties as compared to single FT-PVA hydrogel system, demonstrating the potential to be used for restenosis prevention and as materials for synthetic vascular graft construction. | |
dc.language.iso | en | |
dc.subject | Nitric oxide, controlled release, restenosis, nanoparticle, S-nitrosothiols, poly(vinyl alcohol) | |
dc.type | Thesis | |
dc.contributor.department | MECHANICAL ENGINEERING | |
dc.contributor.supervisor | THIAN ENG SAN | |
dc.contributor.supervisor | LI JUN | |
dc.contributor.supervisor | TEOH SWEE HIN | |
dc.description.degree | Ph.D | |
dc.description.degreeconferred | DOCTOR OF PHILOSOPHY | |
dc.identifier.isiut | NOT_IN_WOS | |
Appears in Collections: | Ph.D Theses (Open) |
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File | Description | Size | Format | Access Settings | Version | |
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Thesis-Zhang QY.pdf | 5.7 MB | Adobe PDF | OPEN | None | View/Download |
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