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|Title:||ELECTROSPUN BIOMIMETIC AND PHOTOSENSITIVE NANOFIBROUS SCAFFOLD FOR SKIN TISSUE ENGINEERING||Authors:||JIN GUORUI||Keywords:||Skin tissue engineering, stem cell, biomimetic scaffold, electrospun nanofibers, drug release, photosensitive scaffold||Issue Date:||19-Aug-2013||Citation:||JIN GUORUI (2013-08-19). ELECTROSPUN BIOMIMETIC AND PHOTOSENSITIVE NANOFIBROUS SCAFFOLD FOR SKIN TISSUE ENGINEERING. ScholarBank@NUS Repository.||Abstract:||Tissue engineering has emerged as a new and promising field for the treatment of skin lesions, combining scaffolds, cells and biomolecular signals, such as growth factors. However, a critical issue of tissue engineered scaffold is the ex vivo cell expansion which is required to obtain sufficient numbers of the needed cells, while preserving the cells' normal phenotype and functionality within a short time. Interestingly, light and electrical stimulations were found to promote cell proliferation. In this project, epidermal growth factor (EGF) and photosensitive polymer poly(3-hexylthiophene) (P3HT) were encapsulated into core-shell NFS. Fibroblast proliferation was significantly improved on EGF encapsulated nanofibers and photosensitive P3HT in the core-shell nanofibers can further promoted fibroblast proliferation under light stimulation. Our study sheds light on a novel way for wound healing - photocurrent therapy.||URI:||http://scholarbank.nus.edu.sg/handle/10635/49373|
|Appears in Collections:||Ph.D Theses (Open)|
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