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Title: Age-related effects of apolipoprotein E genotypes on cholesterol metabolism and insulin signaling
Authors: ONG QI RUI
Keywords: apolipoprotein E, insulin, cholesterol, aging, glucose, mouse models
Issue Date: 14-Dec-2012
Citation: ONG QI RUI (2012-12-14). Age-related effects of apolipoprotein E genotypes on cholesterol metabolism and insulin signaling. ScholarBank@NUS Repository.
Abstract: Apolipoprotein E (ApoE) plays an important role in the regulation of lipid metabolism in the hepatic and central nervous system (CNS). HuApoE4 carriers have been associated with higher peripheral cholesterol level and increased risk for atherosclerosis. Surprisingly, my data showed that huApoE4 has little impact on brain cholesterol metabolism. My data showed that the human Niemann-Pick type C (NPC) disease exhibits varying ApoE present in its CNS. Genetic modified huApoE3/E4 mouse models were also used to study the effects of huApoE genetic polymorphism. These animals exhibited distinct glucose metabolic profiles and changes in the PI3K/AKT signalling pathway. Similar observations were made in the peripheral and CNS. These findings uncovered potential molecular pathways associated with glucose dysfunction. Collectively, my data suggests a novel role for huApoE in regulating brain insulin signalling.
Appears in Collections:Ph.D Theses (Open)

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