Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0264-410X(02)00485-1
DC FieldValue
dc.titleExpression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization
dc.contributor.authorWolfowicz, C.B.
dc.contributor.authorHuangFu, T.
dc.contributor.authorChua, K.Y.
dc.date.accessioned2013-11-18T08:29:07Z
dc.date.available2013-11-18T08:29:07Z
dc.date.issued2003
dc.identifier.citationWolfowicz, C.B., HuangFu, T., Chua, K.Y. (2003). Expression and immunogenicity of the major house dust mite allergen Der p 1 following DNA immunization. Vaccine 21 (11-12) : 1195-1204. ScholarBank@NUS Repository. https://doi.org/10.1016/S0264-410X(02)00485-1
dc.identifier.issn0264410X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/47896
dc.description.abstractThe mite protein Der p 1 is a major trigger of allergy and atopic asthma world-wide, and thus, a good vaccine candidate for allergy prevention. Since it is a cysteine protease, the catalytic effects of Der p 1 vaccination may be unpredictable. One approach to reduce this risk is to vaccinate with DNA encoding enzymatically inactive forms of Der p 1. Here we show that Der p 1 DNA without its native pre-pro sequences potently induced Der p 1-specific antibodies, as long as its pre-sequence was substituted by another leader sequence. Without any pre-pro sequence, the same DNA fragment was well expressed but failed to induce significant level of anti-Der p 1 antibodies, without further boosting by protein. © 2002 Elsevier Science Ltd. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0264-410X(02)00485-1
dc.sourceScopus
dc.subjectDer p 1
dc.subjectDNA vaccine
dc.subjectNaked DNA
dc.typeArticle
dc.contributor.departmentPAEDIATRICS
dc.description.doi10.1016/S0264-410X(02)00485-1
dc.description.sourcetitleVaccine
dc.description.volume21
dc.description.issue11-12
dc.description.page1195-1204
dc.description.codenVACCD
dc.identifier.isiut000181058800023
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

24
checked on Jan 18, 2022

WEB OF SCIENCETM
Citations

23
checked on Jan 18, 2022

Page view(s)

136
checked on Jan 20, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.