ORGANOCATALYTIC ASYMMETRIC SUBSTITUTION REACTIONS OF MORITA-BAYLIS-HILLMAN CARBONATES

Abstract

The organocatalytic asymmetric reaction of Mortia-Baylis-Hillman (MBH) adducts has been received much attention. The asymmetric allylic substitution reaction of MBH carbonates was well studied in the nucleophilic catalyst to achieve useful compounds. In this thesis, two types of nucleophiles were used in the asymmetric substitution reaction of MBH carbonates. Nitroalkanes, which are valuable nucleophiles, have been applied in the organocatalytic asymmetric substitution of MBH carbonates. The specified azlactone, 4-isopropyl-2-oxazolin-5-one which was used as masked formyl anion, has been also utilized in the allylation reaction of MBH carbonates.