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Title: In vitro and in vivo studies into the antidiabetic and antilipidemic effects of chlorogenic acid
Keywords: Vernonia amygdalina, chlorogenic acid, diabetes, gluconeogenesis, glucose transport, GLUT 4
Issue Date: 8-Jan-2013
Citation: ONG KHANG WEI (2013-01-08). In vitro and in vivo studies into the antidiabetic and antilipidemic effects of chlorogenic acid. ScholarBank@NUS Repository.
Abstract: The present author investigated the effects of CGA on glucose and lipid metabolism in Leprdb/db mice. Hepatoma HepG2 was used to investigate CGA?s effect on hepatic glucose production and fatty acid synthesis while L6 myotubes was used to further strengthen our findings in animal skeletal muscles. Subsequently, he attempted to evaluate whether these effects of CGA are associated with the activation of AMPK. In Leprdb/db mice, acute treatment with CGA lowered AUCglucose in an OGTT. Chronic administration of CGA inhibited hepatic G6Pase expression and activity, attenuated hepatic steatosis, improved lipid profiles and skeletal muscle glucose uptake, which in turn improved fasting glucose level, glucose tolerance, insulin sensitivity and dyslipidemia in Leprdb/db mice. CGA activated CAMKK and AMPK, leading to subsequent beneficial metabolic outcomes, such as suppression of hepatic glucose production, fatty acid synthesis and glucose uptake in skeletal muscles. In conclusion, CGA improved glucose and lipid metabolism, via the CAMKK-dependent activation of AMPK.
Appears in Collections:Ph.D Theses (Open)

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