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https://doi.org/10.1016/j.biosystems.2012.06.001
Title: | A cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming | Authors: | Lu, K. Cao, T. Gordon, R. |
Keywords: | Dedifferentiation Development Differentiation Embryogenesis Embryonic stem cell Epigenetics Induced pluripotent stem cell Mechanobiology Mechanotransduction Organizer Reprogramming Theoretical biology Transdifferentiation |
Issue Date: | 2012 | Citation: | Lu, K., Cao, T., Gordon, R. (2012). A cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming. BioSystems 109 (3) : 390-396. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biosystems.2012.06.001 | Abstract: | Cell fate determination and development is a biology question that has yet to be fully answered. During embryogenesis and . in vivo stem cell differentiation, cells/tissues deploy epigenetic mechanisms to accomplish differentiation and give rise to the fully developed organism. Although a biochemistry description of cellular genetics and epigenetics is important, additional mechanisms are necessary to completely solve the problem of embryogenesis, especially differentiation and the spatiotemporal coordination of cells/tissues during morphogenesis. The cell state splitter and differentiation wave working-model was initially proposed to explain the homeostatic primary neural induction in amphibian embryos. Here the model is adopted to explain experimental findings on . in vitro embryonic stem cell, pluripotency and differentiation. Moreover, since somatic cells can be reverted to a stem-cell-like pluripotent state through the laboratory procedure called epigenetic reprogramming, erection of a cell state splitter could be a key event in their successful reprogramming. Overall, the cell state splitter working-model introduces a bistable cytoskeletal mechanism that partially explains cell fate determination and biological development. It offers an interdisciplinary framework that bridges the gap between molecular epigenetics and embryogenesis. © 2012 Elsevier Ireland Ltd. | Source Title: | BioSystems | URI: | http://scholarbank.nus.edu.sg/handle/10635/47163 | ISSN: | 03032647 | DOI: | 10.1016/j.biosystems.2012.06.001 |
Appears in Collections: | Staff Publications |
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