Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.biosystems.2012.06.001
DC FieldValue
dc.titleA cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming
dc.contributor.authorLu, K.
dc.contributor.authorCao, T.
dc.contributor.authorGordon, R.
dc.date.accessioned2013-10-16T07:24:30Z
dc.date.available2013-10-16T07:24:30Z
dc.date.issued2012
dc.identifier.citationLu, K., Cao, T., Gordon, R. (2012). A cell state splitter and differentiation wave working-model for embryonic stem cell development and somatic cell epigenetic reprogramming. BioSystems 109 (3) : 390-396. ScholarBank@NUS Repository. https://doi.org/10.1016/j.biosystems.2012.06.001
dc.identifier.issn03032647
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/47163
dc.description.abstractCell fate determination and development is a biology question that has yet to be fully answered. During embryogenesis and . in vivo stem cell differentiation, cells/tissues deploy epigenetic mechanisms to accomplish differentiation and give rise to the fully developed organism. Although a biochemistry description of cellular genetics and epigenetics is important, additional mechanisms are necessary to completely solve the problem of embryogenesis, especially differentiation and the spatiotemporal coordination of cells/tissues during morphogenesis. The cell state splitter and differentiation wave working-model was initially proposed to explain the homeostatic primary neural induction in amphibian embryos. Here the model is adopted to explain experimental findings on . in vitro embryonic stem cell, pluripotency and differentiation. Moreover, since somatic cells can be reverted to a stem-cell-like pluripotent state through the laboratory procedure called epigenetic reprogramming, erection of a cell state splitter could be a key event in their successful reprogramming. Overall, the cell state splitter working-model introduces a bistable cytoskeletal mechanism that partially explains cell fate determination and biological development. It offers an interdisciplinary framework that bridges the gap between molecular epigenetics and embryogenesis. © 2012 Elsevier Ireland Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.biosystems.2012.06.001
dc.sourceScopus
dc.subjectDedifferentiation
dc.subjectDevelopment
dc.subjectDifferentiation
dc.subjectEmbryogenesis
dc.subjectEmbryonic stem cell
dc.subjectEpigenetics
dc.subjectInduced pluripotent stem cell
dc.subjectMechanobiology
dc.subjectMechanotransduction
dc.subjectOrganizer
dc.subjectReprogramming
dc.subjectTheoretical biology
dc.subjectTransdifferentiation
dc.typeArticle
dc.contributor.departmentDENTISTRY
dc.description.doi10.1016/j.biosystems.2012.06.001
dc.description.sourcetitleBioSystems
dc.description.volume109
dc.description.issue3
dc.description.page390-396
dc.description.codenBSYMB
dc.identifier.isiut000308840500013
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