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https://doi.org/10.1259/dmfr/66925194
DC Field | Value | |
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dc.title | A comparison of the thresholding strategies of micro-CT for periodontal bone loss: A pilot study | |
dc.contributor.author | Chang, P.-C. | |
dc.contributor.author | Liang, K. | |
dc.contributor.author | Lim, J.C. | |
dc.contributor.author | Chung, M-C. | |
dc.contributor.author | Chien, L-Y. | |
dc.date.accessioned | 2013-10-16T07:24:27Z | |
dc.date.available | 2013-10-16T07:24:27Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Chang, P.-C., Liang, K., Lim, J.C., Chung, M-C., Chien, L-Y. (2013). A comparison of the thresholding strategies of micro-CT for periodontal bone loss: A pilot study. Dentomaxillofacial Radiology 42 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1259/dmfr/66925194 | |
dc.identifier.issn | 0250832X | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/47161 | |
dc.description.abstract | Objectives: Micro-CT provides three-dimensional details and has been widely used for biomedical assessments. This study aimed to determine the most appropriate threshold method for quantitatively assessing the dynamics of periodontal destruction. Methods: Inflammation was induced by submerging a silk ligature in the sulcus of the maxillary second molars of rats, and the animals were killed prior to ligature placement and after 7 and 21 days. The maxillae were examined for the bone resorptive activities by micro-CT, histology and tartrate-resistant acid phosphatase staining. The imaging threshold was determined by CT phantom, global and local algorithms. A bone fraction measurement from each thresholddetermining technique was compared with histomorphometry. The reliability and reproducibility were examined by the intraclass correlation coefficient (ICC) and the coefficient of variation. Results: Significant reduction of inflammatory infiltration (p,0.01) and active osteoclastic resorption (p,0.05) from Day 7 to Day 21 were noted. High inter- and intraexaminer agreement were demonstrated in both histomorphometric and micro-CT assessments (ICC.0.98). The algorithm-based technique demonstrated stronger correlation to histomorphometry than phantom-based thresholds, and the highest agreement was presented by the local algorithm (ICC.0.96). This, however, was considerably computationally expensive. Conclusions: The local threshold-determining algorithm is suggested for examining inflammation-induced bone loss. Further investigation will be aimed at enhancing computational efficiency. Dentomaxillofacial Radiology (2013) 42, 66925194. © 2013 The British Institute of Radiology. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1259/dmfr/66925194 | |
dc.source | Scopus | |
dc.subject | Histology | |
dc.subject | Periodontitis | |
dc.subject | X-ray microtomography | |
dc.type | Article | |
dc.contributor.department | DENTISTRY | |
dc.description.doi | 10.1259/dmfr/66925194 | |
dc.description.sourcetitle | Dentomaxillofacial Radiology | |
dc.description.volume | 42 | |
dc.description.issue | 2 | |
dc.description.page | - | |
dc.description.coden | DREAC | |
dc.identifier.isiut | 000315829100006 | |
Appears in Collections: | Staff Publications |
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