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Title: A comparison of the thresholding strategies of micro-CT for periodontal bone loss: A pilot study
Authors: Chang, P.-C. 
Liang, K.
Lim, J.C.
Chung, M-C.
Chien, L-Y.
Keywords: Histology
X-ray microtomography
Issue Date: 2013
Citation: Chang, P.-C., Liang, K., Lim, J.C., Chung, M-C., Chien, L-Y. (2013). A comparison of the thresholding strategies of micro-CT for periodontal bone loss: A pilot study. Dentomaxillofacial Radiology 42 (2) : -. ScholarBank@NUS Repository.
Abstract: Objectives: Micro-CT provides three-dimensional details and has been widely used for biomedical assessments. This study aimed to determine the most appropriate threshold method for quantitatively assessing the dynamics of periodontal destruction. Methods: Inflammation was induced by submerging a silk ligature in the sulcus of the maxillary second molars of rats, and the animals were killed prior to ligature placement and after 7 and 21 days. The maxillae were examined for the bone resorptive activities by micro-CT, histology and tartrate-resistant acid phosphatase staining. The imaging threshold was determined by CT phantom, global and local algorithms. A bone fraction measurement from each thresholddetermining technique was compared with histomorphometry. The reliability and reproducibility were examined by the intraclass correlation coefficient (ICC) and the coefficient of variation. Results: Significant reduction of inflammatory infiltration (p,0.01) and active osteoclastic resorption (p,0.05) from Day 7 to Day 21 were noted. High inter- and intraexaminer agreement were demonstrated in both histomorphometric and micro-CT assessments (ICC.0.98). The algorithm-based technique demonstrated stronger correlation to histomorphometry than phantom-based thresholds, and the highest agreement was presented by the local algorithm (ICC.0.96). This, however, was considerably computationally expensive. Conclusions: The local threshold-determining algorithm is suggested for examining inflammation-induced bone loss. Further investigation will be aimed at enhancing computational efficiency. Dentomaxillofacial Radiology (2013) 42, 66925194. © 2013 The British Institute of Radiology.
Source Title: Dentomaxillofacial Radiology
ISSN: 0250832X
DOI: 10.1259/dmfr/66925194
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