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Title: Microorganism adhesion inhibited by silver doped Yttria-stabilized zirconia ceramics
Authors: Xu, K.
Liu, Y. 
Liu, S.
Liu, A.
Liu, P.
Liu, L.
Li, L.
Keywords: Biomedical applications
Silver Nanoparticles
Y2O3 and ZrO 2
Issue Date: 2011
Citation: Xu, K., Liu, Y., Liu, S., Liu, A., Liu, P., Liu, L., Li, L. (2011). Microorganism adhesion inhibited by silver doped Yttria-stabilized zirconia ceramics. Ceramics International 37 (7) : 2109-2115. ScholarBank@NUS Repository.
Abstract: The aim of this study was to incorporate silver nanoparticles into yttria-stabilized zirconia (YSZ) ceramic for eliminating microorganism adhesion on dental restoration graft. Y2O3 (3% mol) partially stabilized ZrO2 powder with particle size around 80 nm was employed to fabricate tetragonal phase dominated YSZ ceramic block. Silver nanoparticles were efficiently loaded at pH 9.5 by NaBH4 reducing of AgNO 3. The biocompatibility of silver incorporated YSZ was evaluated by MTT assay. Antimicrobial activities were quantitatively determined by optical density measurement and qualitatively analysed by scanning electro microscope. Inductively coupled plasma-mass spectrometry (ICP-MS) revealed that YSZ block containing 0.0047 wt% nanosilver, which is safe to mammalian cell, can inhibit the growth of Escherichia coli, Streptococcus mitis and Candida albicans. The pristine YSZ disc had no effect on bacterial growth. This study suggests that silver nanoparticles incorporated into YSZ blocks possess a broad spectrum antimicrobial effect and may help prevent biofilm formation on their surfaces to improve implant survival rate. © 2011 Elsevier Ltd and Techna Group S.r.l. All rights reserved.
Source Title: Ceramics International
ISSN: 02728842
DOI: 10.1016/j.ceramint.2011.02.023
Appears in Collections:Staff Publications

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