Please use this identifier to cite or link to this item: https://doi.org/10.1088/1748-6041/4/2/021001
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dc.titleHistological evaluation of osteogenesis of 3D-printed poly-lactic-co- glycolic acid (PLGA) scaffolds in a rabbit model
dc.contributor.authorGe, Z.
dc.contributor.authorTian, X.
dc.contributor.authorHeng, B.C.
dc.contributor.authorFan, V.
dc.contributor.authorYeo, J.F.
dc.contributor.authorCao, T.
dc.date.accessioned2013-10-16T05:19:37Z
dc.date.available2013-10-16T05:19:37Z
dc.date.issued2009
dc.identifier.citationGe, Z., Tian, X., Heng, B.C., Fan, V., Yeo, J.F., Cao, T. (2009). Histological evaluation of osteogenesis of 3D-printed poly-lactic-co- glycolic acid (PLGA) scaffolds in a rabbit model. Biomedical Materials 4 (2) : -. ScholarBank@NUS Repository. https://doi.org/10.1088/1748-6041/4/2/021001
dc.identifier.issn17486041
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/46596
dc.description.abstractUtilizing a suitable combination of lactide and glycolide in a copolymer would optimize the degradation rate of a scaffold upon implantation in situ. Moreover, 3D printing technology enables customizing the shape of the scaffold to biometric data from CT and MRI scans. A previous in vitro study has shown that novel 3D-printed poly-lactic-co-glycolic acid (PLGA) scaffolds had good biocompatibility and mechanical properties comparable with human cancellous bone, while they could support proliferation and osteogenic differentiation of osteoblasts. Based on the previous study, this study evaluated PLGA scaffolds for bone regeneration within a rabbit model. The scaffolds were implanted at two sites on the same animal, within the periosteum and within bi-cortical bone defects on the iliac crest. Subsequently, the efficacy of bone regeneration within the implanted scaffolds was evaluated at 4, 12 and 24 weeks post-surgery through histological analysis. In both the intra-periosteum and iliac bone defect models, the implanted scaffolds facilitated new bone tissue formation and maturation over the time course of 24 weeks, even though there was initially observed to be little tissue ingrowth within the scaffolds at 4 weeks post-surgery. Hence, the 3D-printed porous PLGA scaffolds investigated in this study displayed good biocompatibility and are osteoconductive in both the intra-periosteum and iliac bone defect models. © 2009 IOP Publishing Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1088/1748-6041/4/2/021001
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentORAL AND MAXILLOFACIAL SURGERY
dc.description.doi10.1088/1748-6041/4/2/021001
dc.description.sourcetitleBiomedical Materials
dc.description.volume4
dc.description.issue2
dc.description.page-
dc.identifier.isiut000264935500001
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