Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/43616
DC FieldValue
dc.titleCHARACTERIZATION OF A BI-LOBE ASSOCIATED RANGAP TRYPANOSOMA BRUCEI
dc.contributor.authorSHIMA BAYAT
dc.date.accessioned2013-08-31T18:02:17Z
dc.date.available2013-08-31T18:02:17Z
dc.date.issued2013-01-15
dc.identifier.citationSHIMA BAYAT (2013-01-15). CHARACTERIZATION OF A BI-LOBE ASSOCIATED RANGAP TRYPANOSOMA BRUCEI. ScholarBank@NUS Repository.
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/43616
dc.description.abstractTrypanosoma brucei is the causative agent of African trypanosomaisis. This single-cell parasite contains a single flagellum important for cell movement, division and morphogenesis. A bi-lobed structure locates at the proximal base of the single flagellum and is tightly linked to the flagellum. A leucine-rich repeats (LRR) containing protein TbLRRP1 present on the bilobe is essential for bilobe duplication, flagellar attachment and cell motility. To understand the molecular mechanism of TbLRRP1 and to further investigate the function of the bilobe, I used a yeast-two-hybrid screening to search for proteins interacting with TbLRRP1. Yeast-two-hybrid screening resulted in a number of potential binding candidates. A previously uncharacterized, putative Ran-binding domain containing protein was of particular interest. TbLRRP1 formed a functional complex with small GTPase Ran and a Ran-binding domain containing protein in T. brucei and was required for Ran activation. These findings provide new insight to the mechanistic of the bi-lobed structure.
dc.language.isoen
dc.subjectBi-lobe, Flagellum, LRRP1, RanGAP, Ran, T.brucei
dc.typeThesis
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.supervisorHE YINGXIN, CYNTHIA
dc.description.degreePh.D
dc.description.degreeconferredDOCTOR OF PHILOSOPHY
dc.identifier.isiutNOT_IN_WOS
Appears in Collections:Ph.D Theses (Open)

Show simple item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
Bayat-Sh.pdf4.51 MBAdobe PDF

OPEN

NoneView/Download

Page view(s)

193
checked on May 21, 2019

Download(s)

39
checked on May 21, 2019

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.