Please use this identifier to cite or link to this item: https://doi.org/10.1038/ng.2295
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dc.titleGenome-wide survey of recurrent HBV integration in hepatocellular carcinoma
dc.contributor.authorSung, W.-K.
dc.contributor.authorZheng, H.
dc.contributor.authorLi, S.
dc.contributor.authorChen, R.
dc.contributor.authorLiu, X.
dc.contributor.authorLi, Y.
dc.contributor.authorLee, N.P.
dc.contributor.authorLee, W.H.
dc.contributor.authorAriyaratne, P.N.
dc.contributor.authorTennakoon, C.
dc.contributor.authorMulawadi, F.H.
dc.contributor.authorWong, K.F.
dc.contributor.authorLiu, A.M.
dc.contributor.authorPoon, R.T.
dc.contributor.authorFan, S.T.
dc.contributor.authorChan, K.L.
dc.contributor.authorGong, Z.
dc.contributor.authorHu, Y.
dc.contributor.authorLin, Z.
dc.contributor.authorWang, G.
dc.contributor.authorZhang, Q.
dc.contributor.authorBarber, T.D.
dc.contributor.authorChou, W.-C.
dc.contributor.authorAggarwal, A.
dc.contributor.authorHao, K.
dc.contributor.authorZhou, W.
dc.contributor.authorZhang, C.
dc.contributor.authorHardwick, J.
dc.contributor.authorBuser, C.
dc.contributor.authorXu, J.
dc.contributor.authorKan, Z.
dc.contributor.authorDai, H.
dc.contributor.authorMao, M.
dc.contributor.authorReinhard, C.
dc.contributor.authorWang, J.
dc.contributor.authorLuk, J.M.
dc.date.accessioned2013-07-23T09:32:16Z
dc.date.available2013-07-23T09:32:16Z
dc.date.issued2012
dc.identifier.citationSung, W.-K., Zheng, H., Li, S., Chen, R., Liu, X., Li, Y., Lee, N.P., Lee, W.H., Ariyaratne, P.N., Tennakoon, C., Mulawadi, F.H., Wong, K.F., Liu, A.M., Poon, R.T., Fan, S.T., Chan, K.L., Gong, Z., Hu, Y., Lin, Z., Wang, G., Zhang, Q., Barber, T.D., Chou, W.-C., Aggarwal, A., Hao, K., Zhou, W., Zhang, C., Hardwick, J., Buser, C., Xu, J., Kan, Z., Dai, H., Mao, M., Reinhard, C., Wang, J., Luk, J.M. (2012). Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nature Genetics 44 (7) : 765-769. ScholarBank@NUS Repository. https://doi.org/10.1038/ng.2295
dc.identifier.issn10614036
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/43372
dc.description.abstractTo survey hepatitis B virus (HBV) integration in liver cancer genomes, we conducted massively parallel sequencing of 81 HBV-positive and 7 HBV-negative hepatocellular carcinomas (HCCs) and adjacent normal tissues. We found that HBV integration is observed more frequently in the tumors (86.4%) than in adjacent liver tissues (30.7%). Copy-number variations (CNVs) were significantly increased at HBV breakpoint locations where chromosomal instability was likely induced. Approximately 40% of HBV breakpoints within the HBV genome were located within a 1,800-bp region where the viral enhancer, X gene and core gene are located. We also identified recurrent HBV integration events (in ≥4 HCCs) that were validated by RNA sequencing (RNA-seq) and Sanger sequencing at the known and putative cancer-related TERT, MLL4 and CCNE1 genes, which showed upregulated gene expression in tumor versus normal tissue. We also report evidence that suggests that the number of HBV integrations is associated with patient survival. © 2012 Nature America, Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1038/ng.2295
dc.sourceScopus
dc.typeReview
dc.contributor.departmentPHARMACOLOGY
dc.contributor.departmentCOMPUTER SCIENCE
dc.contributor.departmentCANCER SCIENCE INSTITUTE OF SINGAPORE
dc.description.doi10.1038/ng.2295
dc.description.sourcetitleNature Genetics
dc.description.volume44
dc.description.issue7
dc.description.page765-769
dc.description.codenNGENE
dc.identifier.isiut000305886900009
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