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Title: Quantitative and qualitative retinal microvascular characteristics and blood pressure
Authors: Cheung, C.Y. 
Tay, W.T.
Mitchell, P.
Wang, J.J.
Hsu, W. 
Lee, M.L. 
Lau, Q.P. 
Zhu, A.L.
Klein, R.
Saw, S.M. 
Wong, T.Y. 
Keywords: arterioles
Issue Date: 2011
Citation: Cheung, C.Y., Tay, W.T., Mitchell, P., Wang, J.J., Hsu, W., Lee, M.L., Lau, Q.P., Zhu, A.L., Klein, R., Saw, S.M., Wong, T.Y. (2011). Quantitative and qualitative retinal microvascular characteristics and blood pressure. Journal of Hypertension 29 (7) : 1380-1391. ScholarBank@NUS Repository.
Abstract: Objective: The present study examined the effects of blood pressure on a spectrum of quantitative and qualitative retinal microvascular signs. Methods: Retinal photographs from the Singapore Malay Eye Study, a population-based cross-sectional study of 3280 (78.7% response) persons aged 40-80 years, were analyzed. Quantitative changes in the retinal vasculature (branching angle, vascular tortuosity, fractal dimension, and vascular caliber) were measured using a semi-automated computer-based program. Qualitative signs, including focal arteriolar narrowing (FAN), arteriovenous nicking (AVN), opacification of the arteriolar wall (OAW), and retinopathy (e.g., microaneurysms, retinal hemorrhages), were assessed from photographs by trained technicians. After excluding persons with diabetes and ungradable photographs, 1913 persons provided data for this analysis. Results: In multivariable linear regression models controlling for age, sex, BMI, use of antihypertensive medication, and other factors, retinal arteriolar branching asymmetry ratio, arteriolar tortuosity, venular tortuosity, fractal dimension, arteriolar caliber, venular caliber, FAN, AVN, and retinopathy were independently associated with mean arterial blood pressure. In contrast, arteriolar/venular branching angle, venular branching asymmetry ratio and OAW were not related to blood pressure. Retinal arteriolar caliber (sβ = -0.277) and FAN (sβ = 0.170) had the strongest associations with mean arterial blood pressure, and higher blood pressure levels were associated with increasing number of both quantitative and qualitative retinal vascular signs (P trend <0.001). Conclusion: Elevated blood pressure is associated with a spectrum of quantitative and qualitative retinal vascular signs, with the number of signs increasing with higher blood pressure levels. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Source Title: Journal of Hypertension
ISSN: 02636352
DOI: 10.1097/HJH.0b013e328347266c
Appears in Collections:Staff Publications

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