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Title: Nuclei extraction from histopathological images using a marked point process approach
Authors: Kulikova, M.
Veillard, A.
Roux, L.
Racoceanu, D. 
Keywords: Active contour
Breast cancer grading
Digital histopathology
H&E image
Marked point processes
Nuceli extraction
Issue Date: 2012
Citation: Kulikova, M., Veillard, A., Roux, L., Racoceanu, D. (2012). Nuclei extraction from histopathological images using a marked point process approach. Progress in Biomedical Optics and Imaging - Proceedings of SPIE 8314. ScholarBank@NUS Repository.
Abstract: Morphology of cell nuclei is a central aspect in many histopathological studies, in particular in breast cancer grading. Therefore, the automatic detection and extraction of cell nuclei from microscopic images obtained from cancer tissue slides is one of the most important problems in digital histopathology. We propose to tackle the problem using a model based on marked point processes (MPP), a methodology for extraction of multiple objects from images. The advantage of MPP based models is their ability to take into account the geometry of objects; and the information about their spatial repartition in the image. Previously, the MPP models have been applied for the extraction of objects of simple geometrical shapes. For histolog-ical grading, a morphological criterion known as nuclear pleomorphism corresponding to fine morphological differences between the nuclei is assessed by pathologists. Therefore, the accurate delineation of nuclei became an issue of even greater importance than optimal nuclei detection. Recently, the MPP framework has been defined on the space of arbitrarily-shaped objects allowing more accurate extraction of complex-shaped objects. The nuclei often appear joint or even overlap in histopathological images. The model still allows to extract them as individual joint or overlapping objects without discarding the overlapping parts and therefore without significant loss in delineation precision. We aim to compare the MPP model with two state-of-the-art methods selected from a comprehensive review of the available methods. The experiments are performed using a database of H&E stained breast cancer images covering a wide range of histological grades. © 2012 SPIE.
Source Title: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ISBN: 9780819489630
ISSN: 16057422
DOI: 10.1117/12.911757
Appears in Collections:Staff Publications

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