Please use this identifier to cite or link to this item:
https://doi.org/10.1128/MCB.05958-11
DC Field | Value | |
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dc.title | Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival | |
dc.contributor.author | Tan, P.Y. | |
dc.contributor.author | Chang, C.W. | |
dc.contributor.author | Chng, K.R. | |
dc.contributor.author | Senali Abayratna Wansa, K.D. | |
dc.contributor.author | Sung, W.-K. | |
dc.contributor.author | Cheung, E. | |
dc.date.accessioned | 2013-07-04T07:40:11Z | |
dc.date.available | 2013-07-04T07:40:11Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Tan, P.Y., Chang, C.W., Chng, K.R., Senali Abayratna Wansa, K.D., Sung, W.-K., Cheung, E. (2012). Integration of regulatory networks by NKX3-1 promotes androgen-dependent prostate cancer survival. Molecular and Cellular Biology 32 (2) : 399-414. ScholarBank@NUS Repository. https://doi.org/10.1128/MCB.05958-11 | |
dc.identifier.issn | 02707306 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/39374 | |
dc.description.abstract | The NKX3-1 gene is a homeobox gene required for prostate tumor progression, but how it functions is unclear. Here, using chromatin immunoprecipitation coupled to massively parallel sequencing (ChIP-seq) we showed that NKX3-1 colocalizes with the androgen receptor (AR) across the prostate cancer genome. We uncovered two distinct mechanisms by which NKX3-1 controls the AR transcriptional network in prostate cancer. First, NKX3-1 and AR directly regulate each other in a feed-forward regulatory loop. Second, NKX3-1 collaborates with AR and FoxA1 to mediate genes in advanced and recurrent prostate carcinoma. NKX3-1- and AR-coregulated genes include those found in the "protein trafficking" process, which integrates oncogenic signaling pathways. Moreover, we demonstrate that NKX3-1, AR, and FoxA1 promote prostate cancer cell survival by directly upregulating RAB3B, a member of the RAB GTPase family. Finally, we show that RAB3B is overexpressed in prostate cancer patients, suggesting that RAB3B together with AR, FoxA1, and NKX3-1 are important regulators of prostate cancer progression. Collectively, our work highlights a novel hierarchical transcriptional regulatory network between NKX3-1, AR, and the RAB GTPase signaling pathway that is critical for the genetic-molecular-phenotypic paradigm in androgen-dependent prostate cancer. © 2012, American Society for Microbiology. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1128/MCB.05958-11 | |
dc.source | Scopus | |
dc.type | Article | |
dc.contributor.department | COMPUTER SCIENCE | |
dc.description.doi | 10.1128/MCB.05958-11 | |
dc.description.sourcetitle | Molecular and Cellular Biology | |
dc.description.volume | 32 | |
dc.description.issue | 2 | |
dc.description.page | 399-414 | |
dc.description.coden | MCEBD | |
dc.identifier.isiut | 000299020100014 | |
Appears in Collections: | Staff Publications |
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