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https://doi.org/10.1186/1471-2164-12-S2-S6
Title: | CAMBer: An approach to support comparative analysis of multiple bacterial strains | Authors: | Wozniak, M. Wong, L. Tiuryn, J. |
Issue Date: | 2011 | Citation: | Wozniak, M., Wong, L., Tiuryn, J. (2011). CAMBer: An approach to support comparative analysis of multiple bacterial strains. BMC Genomics 12 (SUPPL.2). ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2164-12-S2-S6 | Abstract: | Background: There is a large amount of inconsistency in gene structure annotations of bacterial strains. This inconsistency is a frustrating impedance to effective comparative genomic analysis of bacterial strains in promising applications such as gaining insights into bacterial drug resistance.Results: Here, we propose CAMBer as an approach to support comparative analysis of multiple bacterial strains. CAMBer produces what we called multigene families. Each multigene family reveals genes that are in one-to-one correspondence in the bacterial strains, thereby permitting their annotations to be integrated. We present results of our method applied to three human pathogens: Escherichia coli, Mycobacterium tuberculosis and Staphylococcus aureus.Conclusions: As a result, more accurate and more comprehensive annotations of the bacterial strains can be produced. © 2011 Wozniak et al; licensee BioMed Central Ltd. | Source Title: | BMC Genomics | URI: | http://scholarbank.nus.edu.sg/handle/10635/39291 | ISSN: | 14712164 | DOI: | 10.1186/1471-2164-12-S2-S6 |
Appears in Collections: | Staff Publications Elements |
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