Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.bbrc.2005.03.074
DC FieldValue
dc.titleAlzheimer's disease: Channeling APP to non-amyloidogenic processing
dc.contributor.authorTang, B.L.
dc.date.accessioned2013-06-05T09:51:34Z
dc.date.available2013-06-05T09:51:34Z
dc.date.issued2005
dc.identifier.citationTang, B.L. (2005). Alzheimer's disease: Channeling APP to non-amyloidogenic processing. Biochemical and Biophysical Research Communications 331 (2) : 375-378. ScholarBank@NUS Repository. https://doi.org/10.1016/j.bbrc.2005.03.074
dc.identifier.issn0006291X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/38365
dc.description.abstractA good number of pharmacologic agents have over the years been touted as potentially beneficial in either preventing the onset or delay the progression of Alzheimer's disease. These include compounds such as non-steroidal anti-inflammatory drugs (NSAIDs) (HMG-CoA reductase inhibitors (statins)) and flavonoids. The underlying mechanisms for the beneficial effect of these agents are by and large attributed to their ability to reduce β-amyloid (Aβ) production and amyloid load in the brain, via inhibition of amyloidogenic γ-secretase activity. Recent reports have now provided mechanistic insights as to how non-amyloidogenic processing might also be enhanced by these seemingly unrelated treatments. Intriguingly, this appears to involve the inhibition of the activity of small GTPase Rho and its effector, the Rho-associated kinase, ROCK. Dietary caloric restriction (CR) also enhances non-amyloidogenic processing of APP, and this may be part of a more general anti-aging effect of CR mediated by gene expression changes downstream of the activity of the histone deacetylase SIRT1. © 2005 Elsevier Inc. All rights reserved.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/j.bbrc.2005.03.074
dc.sourceScopus
dc.subjectβ-Amyloid
dc.subjectAlzheimer's disease
dc.subjectNon-steroidal anti-inflammatory drugs
dc.subjectRho
dc.subjectRho-associated protein kinase
dc.subjectStatins
dc.typeReview
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.1016/j.bbrc.2005.03.074
dc.description.sourcetitleBiochemical and Biophysical Research Communications
dc.description.volume331
dc.description.issue2
dc.description.page375-378
dc.description.codenBBRCA
dc.identifier.isiut000228961000001
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