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https://doi.org/10.1016/S0891-5849(01)00640-2
DC Field | Value | |
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dc.title | Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise | |
dc.contributor.author | Childs, A. | |
dc.contributor.author | Leeuwenburgh, C. | |
dc.contributor.author | Jacobs, C. | |
dc.contributor.author | Kaminski, T. | |
dc.contributor.author | Halliwell, B. | |
dc.date.accessioned | 2013-06-05T09:50:20Z | |
dc.date.available | 2013-06-05T09:50:20Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | Childs, A., Leeuwenburgh, C., Jacobs, C., Kaminski, T., Halliwell, B. (2001). Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise. Free Radical Biology and Medicine 31 (6) : 745-753. ScholarBank@NUS Repository. https://doi.org/10.1016/S0891-5849(01)00640-2 | |
dc.identifier.issn | 08915849 | |
dc.identifier.uri | http://scholarbank.nus.edu.sg/handle/10635/38306 | |
dc.description.abstract | There has been no investigation to determine if the widely used over-the-counter, water-soluble antioxidants vitamin C and N-acetyl-cysteine (NAC) could act as pro-oxidants in humans during inflammatory conditions. We induced an acute-phase inflammatory response by an eccentric arm muscle injury. The inflammation was characterized by edema, swelling, pain, and increases in plasma inflammatory indicators, myeloperoxidase and interleukin-6. Immediately following the injury, subjects consumed a placebo or vitamin C (12.5 mg/kg body weight) and NAC (10 mg/kg body weight) for 7 d. The resulting muscle injury caused increased levels of serum bleomycin-detectable iron and the amount of iron was higher in the vitamin C and NAC group. The concentrations of lactate dehydrogenase (LDH), creatine kinase (CK), and myoglobin were significantly elevated 2, 3, and 4 d postinjury and returned to baseline levels by day 7. In addition, LDH and CK activities were elevated to a greater extent in the vitamin C and NAC group. Levels of markers for oxidative stress (lipid hydroperoxides and 8-iso prostaglandin F2α; 8-Iso-PGF2α) and antioxidant enzyme activities were also elevated post-injury. The subjects receiving vitamin C and NAC had higher levels of lipid hydroperoxides and 8-Iso-PGF2α 2 d after the exercise. This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress. © 2001 Elsevier Science Inc. | |
dc.description.uri | http://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0891-5849(01)00640-2 | |
dc.source | Scopus | |
dc.subject | Antioxidants | |
dc.subject | Ascorbic acid | |
dc.subject | Disease | |
dc.subject | Free radicals | |
dc.subject | Neutrophils | |
dc.subject | Pro-oxidants | |
dc.subject | Sepsis | |
dc.type | Article | |
dc.contributor.department | BIOCHEMISTRY | |
dc.description.doi | 10.1016/S0891-5849(01)00640-2 | |
dc.description.sourcetitle | Free Radical Biology and Medicine | |
dc.description.volume | 31 | |
dc.description.issue | 6 | |
dc.description.page | 745-753 | |
dc.description.coden | FRBME | |
dc.identifier.isiut | 000171124100006 | |
Appears in Collections: | Staff Publications |
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