Please use this identifier to cite or link to this item:
Title: A functional significance for codon third bases
Authors: Epstein, R.J.
Lin, K.
Tan, T.W. 
Keywords: Molecular evolution
Issue Date: 2000
Citation: Epstein, R.J., Lin, K., Tan, T.W. (2000). A functional significance for codon third bases. Gene 245 (2) : 291-298. ScholarBank@NUS Repository.
Abstract: Most amino acids are specified by more than one trinucleotide codon. Here we show that amino acids of differing functional importance may be distinguished by the pattern of synonymous codon usage. GC-rich genes tend to be of a greater transcriptional (p < 0.01) and mitogenic (p < 0.0001) significance than AT-rich genes, consistent with GC→AT mutational drift in methylated genomic regions. Third-base GC retention also identifies critical amino acids within individual proteins, as indicated by non-random patterns of codon variation between gene homologs and also by differential sequelae of site-directed mutagenesis. Sequence analysis of human receptor tyrosine kinase genes confirms that functionally important transmembrane hydrophobic amino acids are specified by codons containing GC third bases more often than are transmembrane neutral amino acids (χ2=134.2). Amino acids encoded by GC third bases thus appear more tightly linked to cell function and survival than are those encoded by AT third bases. (C) 2000 Elsevier Science B.V.
Source Title: Gene
ISSN: 03781119
DOI: 10.1016/S0378-1119(00)00042-1
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Sep 12, 2020


checked on Jul 10, 2019

Page view(s)

checked on Sep 15, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.